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Nectin-2 Antibodies
AND NECTIN2 ELISA kits, Nectin-2 Proteins
Many biological assays use antibodies to detect Nectin-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Nectin-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Nectin-2 antibodies...
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NECTIN2 Infographic by Boster Bio
All NECTIN2 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$499
Cat # EK1960
96 wells/kit, with removable strips.
Cat # EK1960
96 wells/kit, with removable strips.
Human, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A08081-2
100 μg/vial
Cat # A08081-2
100 μg/vial
Human
Flow Cytometry, IP, IHC-F
$299
Cat # M08081
0.1 mg
Cat # M08081
0.1 mg
Human, Mouse, Rat
Flow Cytometry, IP, IF, ICC, WB
$370
Cat # M08081-2
100 μl/vial
Cat # M08081-2
100 μl/vial
NECTIN2 Overview
Facts about Nectin-2.
Nectin-2 (NECTIN2)
Modulator of T-cell signaling.
Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to.Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation.
Gene Information
| Human | |
|---|---|
| Gene Name: | NECTIN2 |
| Uniprot: | Q92692 |
| Entrez: | 5819 |
Family
| Belongs to: |
|---|
| nectin family |
Alternative Names
CD112 antigen; CD112; Herpes virus entry mediator B; Herpesvirus entry mediator B; herpesvirus entry protein B; HVEB; HVEBpoliovirus receptor-like 2; MPH; nectin 2; Nectin2; Nectin-2; poliovirus receptor-related 2 (herpesvirus entry mediator B); poliovirus receptor-related protein 2; PRR2; PRR2nectin-2; PVRL2; PVRR2poliovirus receptor related 2
Molecular Weight
Mass (kDA):
57.742 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19q13.32 |
| Sequence: | 19; NC_000019.10 (44846297..44889223) |
Tissue Specificity
Ubiquitous.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein.
Diseases
- Congenital Abnormality
- Cleft Lip
- Cleft Palate
- Tissue Adhesions
- Malignant Neoplasms
- Neoplasms
- Dysequilibrium Syndrome
- Alzheimer's Disease
- Sclerosis
- Hepatitis B
- Carcinoma
- Lymphoma
- Cytogenetic Abnormality
Interacting Proteins
- AFDN
- CD226
- DNAJC5
- KRTAP10-5
- KRTAP10-7
- KRTAP5-9
- MDFI
- NECTIN3
- NOTCH2NL
- SIAH1
Pathways
- Pathogenesis
- Cell Adhesion
- Transport
- Intracellular Transport
- Cell Proliferation
- Cell-cell Signaling
- Aging
- Cell Differentiation
- Cellular Process
PTMs
- Disulfide bond
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NECTIN2
bosterbio.com/bosterbio-gene-info-cards/NECTIN2
References
PMID: 7622062 by Eberle F., et al. The human PRR2 gene, related to the human poliovirus receptor gene (PVR), is the true homolog of the murine MPH gene.
PMID: 9657005 by Warner M.S., et al. A cell surface protein with herpesvirus entry activity (HveB) confers susceptibility to infection by mutants of herpes simplex virus type 1, herpes simplex virus type 2, and pseudorabies virus.