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NDST2 Antibodies
AND NDST2 ELISA kits, NDST2 Proteins
Many biological assays use antibodies to detect NDST2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NDST2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NDST2 antibodies...
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NDST2 Overview
Facts about Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2.
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 (NDST2)
Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to produce N-sulfated heparosan, a necessity substrate for later modifications in heparin biosynthesis.
Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).
Gene Information
| Human | |
|---|---|
| Gene Name: | NDST2 |
| Uniprot: | P52849 |
| Entrez: | 8509 |
Family
| Belongs to: |
|---|
| sulfotransferase 1 family |
Alternative Names
bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2; EC 2.8.2.8; Glucosaminyl N-deacetylase/N-sulfotransferase 2; HSST2MGC129697; MGC129705; N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2; NDST2; NDST-2; N-heparan sulfate sulfotransferase 2; N-HSST 2; NST2
Molecular Weight
Mass (kDA):
100.875 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10q22.2 |
| Sequence: | 10; NC_000010.11 (73801916..73811820, complement) |
Subcellular Localizations
Golgi apparatus membrane; Single-pass type II membrane protein.
Diseases
- Inflammation
- Neoplasms
- Extravasation
- Chimera Disorder
- Blood Coagulation Disorders
- Tissue Adhesions
- Leukemia
- Diabetic Nephropathy
- Melanoma
- Breast Adenocarcinoma
- Myeloid Leukemia, Chronic
- Tumor Angiogenesis
Pathways
- Sulfation
- Blood Coagulation
- Localization
- Coagulation
- Cell Proliferation
- Gland Development
- Lacrimal Gland Development
- Cell Differentiation
- Cell Activation
- Golgi Localization
- Lung Development
- Osteoblast Proliferation
- Transcytosis
PTMs
- Sulphation
- Deacetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NDST2
bosterbio.com/bosterbio-gene-info-cards/NDST2
References
PMID: 9601056 by Humphries D.E., et al. cDNA cloning, genomic organization and chromosomal localization of human heparan glucosaminyl N-deacetylase/N-sulphotransferase-2.
PMID: 10758005 by Pikas D.S., et al. Overexpression of different isoforms of glucosaminyl N-deacetylase/N- sulfotransferase results in distinct heparan sulfate N-sulfation patterns.