Nicastrin Antibodies

Nicastrin (NCSTN)

Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:10993067, PubMed:12679784, PubMed:25043039, PubMed:26280335). The gamma- secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels.

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Gene Information

Human
Gene Name:	NCSTN
Uniprot:	Q92542
Entrez:	23385

Family

Belongs to:
nicastrin family

Alternative Names

anterior pharynx-defective 2; APH2; ATAG1874; KIAA0253APH2; NCSTN; Nicastrin

Molecular Weight

Mass (kDA):
78.411 kDA

Genomic Context

Human
Location:	1q23.2
Sequence:	1; NC_000001.11 (160343328..160358949)

Tissue Specificity

Detected in brain (at protein level) (PubMed:10993067). Widely expressed (PubMed:11396676).

Subcellular Localizations

Membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Diseases

• Alzheimer's Disease
• Hidradenitis
• Hidradenitis Suppurativa
• Acne
• Dementia
• Malignant Neoplasms
• Alteration Of Cognitive Function
• Impaired Cognition
• Cholangiocarcinoma
• Abscess
• Neurodegenerative Disorders
• Hypoxia
• Malignant Neoplasm Of Urinary Bladder

• Carcinoma
• Nervousness
• Confusion Postoperative
• 5,10-methylenetetrahydrofolate Reductase Deficiency
• Hypercapnia
• Mild Cognitive Disorder
• Neurofibrillary Tangles

Interacting Proteins

• APH1A
• PSEN1
• PSENEN
• TMED10

Pathways

• Pathogenesis
• Transport
• Cognition
• Histone H3 Acetylation
• Viral Latency
• Dna Recombination
• Nuclear Export

• Secretion
• Chromatin Remodeling

PTMs

• Cleavage
• Gamma-cleavage

• Phosphorylation
• Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NCSTN

Boster Bio - Best Uses Of The NCSTN Marker

This article will provide information about Boster Bio’s primary antibodies with high-affinity. We will also discuss the various applications of these antibodies and validate them on different platforms. We will also discuss the best use of the NCSTN markers and how Boster may be able to help you with research. We will also examine the Boster customer satisfaction ratings.

Boster specializes in high-affinity primary antibodies

Sanbio specializes manufacturing high-quality antibodies and ELISA kit kits. Boster Bio was founded by Steven Boster, a biotechnology entrepreneur known for his innovative, high affinity primary antibodies. His first product was an IHC Kit. He went on to create hundreds of primary antibodies and was eventually one of China's most prominent catalog antibody companies. PicoKine (tm), his own proprietary ELISA platform for testing, was also developed. Boster Bio can now deliver high-specific, high affinity ELISA kits to researchers all over the world using this patented platform.

The company's diverse portfolio contains a variety of products that are tailored to the most rigorous research requirements. Picokine (tm) ELISA platform is able to increase ELISA sensitivity down to the picogram scale. Picokine(tm) ELISA kits have been validated for a variety of samples and can be obtained upon request. The company also produces Supervision, a polymer-based secondary antibody that can save researchers up to 30 minutes of time when used in immunohistochemistry. Picoband(tm), an IHC kit powered by insights from immunogen design saves scientists upto 30 minutes. Boster Bio also offers technical assistance from Sanbio and BeNeLux distributor BeNeLux.

Exalpha is a high-affinity antibody manufacturer. Exalpha produces high-affinity goat clonal antibodies, as well other bioactive products. The company produces over 60,000 research product in various fields. Europa Bioproducts offers more than 60,000 research products. They specialize in Phycobiliproteins, monoclonal antibodies, ELISA kits, and cell proliferation assay reagents.

The use of flow cytometry has many applications in science. These high-affinity antibodies allow researchers to detect many proteins in cells as well as particles. These high-affinity antibodies are monoclonal/polyclonal and have received numerous citations over the past 25+ years in scientific journals. Boster is a research tool that allows you to study specific proteins and detect them.

Biotech Source can supply you with any number of monoclonal or single antibodies. The company offers both high-affinity sheep monoclonal antibodies and bulk antigens for diagnostic and research applications. Bioventix, another company with a large antibody line, is also available. They specialize in monoclonal antibodies for sheep. Bioventix produces monoclonal antibodies as well as antigens. They also have a large stock of polyclonal antibody.

HyTest Ltd. not only produces and markets antibody-based products but also makes and markets immunoassays that measure innate immunity. Their portfolio includes a variety of reagents that can be used for cell culture, immunoassays, or molecular biological kits. The company is also very interested in the study of inflammation and cell injury caused by pathogens. These antibodies are a good option for identifying molecules that trigger disease responses.

Primary antibodies with high-affinity

High-affinity primary antibodies are a crucial component of protein purification and immunoprecipitation methods. Boster Bio stocks a variety of valid antibodies for these procedures. Boster Bio also sells rabbit polyclonal antibodies and secondary antibody for specific isotypes. You can also get secondary antibodies free with every primary anti-body purchase. Boster Bio antibodies are guaranteed to retain biological activity.

The Boster Bio antibody range is comprised of more than 12,000 antibodies validated for IHC, WB, ELISA, Flow Cytometry, and ELISA. For optimal performance, the antibodies were rigorously tested against 250 different tissues and cells. They have also been tested against un-transfected cell lines and are suitable for multiple applications. All Boster Bio's antibodies have been validated for multiple uses, including IHC, WB and ELISA.

Flowcytometry has many uses in medicine and science. The technique works by using cells and particles to identify the proteins. Boster Bio's primary antibodies are high-affinity polyclonal antibodies with a high citation count. Flow cytometry can also be used to detect other proteins and antigens. Boster's primary antibodies are high-affinity and can be used for research and discovery.

A dual labeling system for specimens is another reason why you should use a primary-secondary antigen system. Dual labeling allows for you to ask questions that you might not otherwise be able answer. Dual labeling provides you with a richer answer and context that cannot be achieved with a single antigen. These are crucial for high-quality research.