Nicastrin Antibodies

AND NCSTN ELISA kits, Nicastrin Proteins

Many biological assays use antibodies to detect Nicastrin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Nicastrin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Nicastrin antibodies...

We validate the specificity of these antibodies to Nicastrin by testing them on tissues known to express NCSTN positively and negatively. Browse below to find the NCSTN antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NCSTN Infographic by Boster Bio

All NCSTN Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-Nicastrin/NCSTN Antibody Picoband®

1 Q&As

Human

$370
Cat # PA2250
100 μg/vial

Anti-Nicastrin NCSTN Antibody

Human, Mouse, Rat

ELISA, IF, IHC-P, WB

$449
Cat # A03144
0.1 mg

Anti-Nicastrin/NCSTN Antibody Picoband®

Human, Mouse, Rat

ELISA, IF, ICC, WB

$370
Cat # A03144-1
100 μg/vial

Anti-Nicastrin Rabbit Monoclonal Antibody

Human

IF, ICC, WB

$370
Cat # M03144-1
100 μl/vial

Nicastrin (NCSTN) (NM_015331) Human Over-expression Lysate

Human

$960
Cat # LS023385
100 µg

NCSTN Overview

Facts about Nicastrin.

NCSTN 3D structure. Source: alphafold

Nicastrin (NCSTN)

Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:10993067, PubMed:12679784, PubMed:25043039, PubMed:26280335). The gamma- secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels.

Gene Information

Human
Gene Name:	NCSTN
Uniprot:	Q92542
Entrez:	23385

Family

Belongs to:

nicastrin family

Alternative Names

anterior pharynx-defective 2; APH2; ATAG1874; KIAA0253APH2; NCSTN; Nicastrin

Molecular Weight

Mass (kDA):
78.411 kDA

Genomic Context


Human

Location:	1q23.2
Sequence:	1; NC_000001.11 (160343328..160358949)

Tissue Specificity

Detected in brain (at protein level) (PubMed:10993067). Widely expressed (PubMed:11396676).

Subcellular Localizations

Membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.