NCOA6 Antibodies

AND NCOA6 ELISA kits, NCOA6 Proteins

Many biological assays use antibodies to detect NCOA6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NCOA6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NCOA6 antibodies...

We validate the specificity of these antibodies to NCOA6 by testing them on tissues known to express NCOA6 positively and negatively. Browse below to find the NCOA6 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NCOA6 Infographic by Boster Bio

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NCOA6 Overview

Facts about Nuclear receptor coactivator 6.

NCOA6 3D structure. Source: alphafold

Nuclear receptor coactivator 6 (NCOA6)

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent method.

Involved from the coactivation of different nuclear receptors, like for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid gland (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, as opposed to just a nuclear receptor coactivator.

Gene Information

Human
Gene Name:	NCOA6
Uniprot:	Q14686
Entrez:	23054

Family

Belongs to:

No superfamily

Alternative Names

Activating signal cointegrator 2; AIB3NRC RAP250; Amplified in breast cancer protein 3; ASC-2; Cancer-amplified transcriptional coactivator ASC-2; KIAA0181PPAR-interacting protein; NRCamplified in breast cancer-3 protein; nuclear receptor coactivator 6; Nuclear receptor coactivator RAP250; Nuclear receptor-activating protein, 250 kDa; peroxisome proliferator-activated receptor interacting protein; PRIPPeroxisome proliferator-activated receptor-interacting protein; RAP250Thyroid hormone receptor-binding protein; thyroid hormone receptor binding protein; TRBPASC2activating signal cointegrator-2

Molecular Weight

Mass (kDA):
219.145 kDA

Genomic Context


Human

Location:	20q11.22
Sequence:	20; NC_000020.11 (34714774..34825651, complement)

Tissue Specificity

Ubiquitous. Highly expressed in brain, prostate, testis and ovary; weakly expressed in lung, thymus and small intestine.

Subcellular Localizations

Nucleus.

Diseases

Malignant Neoplasms
Neoplasms
Cell Transformation, Neoplastic
Stomach Neoplasms
Pituitary Diseases
Mammary Neoplasms
Inflammation
Insulin Resistance
Obesity
Microphthalmos
Malignant Neoplasm Of Breast
Infertility
Immunologic Deficiency Syndromes

Hepatotoxicity
Neoplasm Recurrence, Local
Liver Carcinoma
Diabetes Mellitus
Cataract
Malignant Neoplasm Of Lung
Carcinogenesis

Interacting Proteins

AR
ASH2L
CREBBP
KMT2B
KMT2C

RB1
TP53BP1
WDR5

Pathways

Methylation
Receptor Transactivation
Cell Proliferation
Gene Silencing
Cell Cycle
Wound Healing
Secretion
Insulin Secretion
Localization
Mammary Gland Development
Histone Methylation
Gland Development
Translation

Endocytosis
Cell Growth
Rna Interference
Osteoblast Differentiation
Mammary Gland Morphogenesis
Embryo Implantation
Cholesterol Efflux

PTMs

Methylation
Phosphorylation
Cleavage

Acetylation
Oxidation
Dephosphorylation

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NCOA6

References

PMID: 10567404 by Lee S.-K., et al. A nuclear factor ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo.

PMID: 10866662 by Mahajan M.A., et al. A new family of nuclear receptor coregulators that integrates nuclear receptor signaling through CBP.