NMNAT2 Antibodies

AND NMNAT2 ELISA kits, NMNAT2 Proteins

Many biological assays use antibodies to detect NMNAT2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NMNAT2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NMNAT2 antibodies...

We validate the specificity of these antibodies to NMNAT2 by testing them on tissues known to express NMNAT2 positively and negatively. Browse below to find the NMNAT2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NMNAT2 Infographic by Boster Bio

All NMNAT2 Products

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Price

NMNAT2 (NM_170706) Human Recombinant Protein

$813
Cat # PROTQ9BZQ4
20 µg

NMNAT2 (NM_170706) Human Over-expression Lysate

Human

$628
Cat # LS023057
100 µg

NMNAT2 Overview

Facts about Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2.

NMNAT2 3D structure. Source: alphafold

Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 (NMNAT2)

Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor (By similarity). Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency (PubMed:16118205, PubMed:17402747).

Cannot use triazofurin monophosphate (TrMP) as substrate (PubMed:16118205, PubMed:17402747). Also catalyzes the reverse reaction, i.

Gene Information

Human
Gene Name:	NMNAT2
Uniprot:	Q9BZQ4
Entrez:	23057

Family

Belongs to:

eukaryotic NMN adenylyltransferase family

Alternative Names

C1orf15; chromosome 1 open reading frame 15; EC 2.7.7.1; EC 2.7.7.18; KIAA0479MGC2756; NaMN adenylyltransferase 2; nicotinamide mononucleotide adenylyltransferase 2; nicotinamide nucleotide adenylyltransferase 2; Nicotinate-nucleotide adenylyltransferase 2; NMN adenylyltransferase 2; NMNAT2; NMNAT-2; PNAT2; pyridine nucleotide adenylyltransferase 2

Molecular Weight

Mass (kDA):
34.439 kDA

Genomic Context


Human

Location:	1q25.3
Sequence:	1; NC_000001.11 (183248237..183418380, complement)

Tissue Specificity

Highly expressed in brain, in particular in cerebrum, cerebellum, occipital lobe, frontal lobe, temporal lobe and putamen. Also found in the heart, skeletal muscle, pancreas and islets of Langerhans.

Subcellular Localizations

Golgi apparatus membrane; Lipid-anchor. Cytoplasmic vesicle membrane; Lipid-anchor. Cytoplasm. Cell projection, axon. Delivered to axons with Golgi-derived cytoplasmic vesicles.

Diseases

Neurodegenerative Disorders
Nerve Degeneration
Wallerian Degeneration
Alzheimer's Disease
Abnormal Degeneration
Frontotemporal Dementia With Parkinsonism
Frontotemporal Dementia
Dementia
Cardiac Hypertrophy
Diabetes Mellitus
Malignant Neoplasms
Hypertrophy

Nervousness
Secondary Parkinson Disease
Memory Impairment
Tauopathies
Alzheimer Disease, Familial
Neurofibrillary Tangles

Pathways

Localization
Transport
Cellular Localization

PTMs

Phosphorylation

Palmitoylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NMNAT2

References

PMID: 11318611 by Sood R., et al. Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus.

PMID: 12359228 by Raffaelli N., et al. Identification of a novel human nicotinamide mononucleotide adenylyltransferase.