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- Table of Contents
Facts about Nuclear receptor coactivator 2.
Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC expression.
Human | |
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Gene Name: | NCOA2 |
Uniprot: | Q15596 |
Entrez: | 10499 |
Belongs to: |
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SRC/p160 nuclear receptor coactivator family |
bHLHe75; bHLHe75MGC138808; Class E basic helix-loop-helix protein 75; EC 2.3.1.48; GRIP1glucocorticoid receptor-interacting protein-1; HTIF2; KAT13C; NCOA2; NCoA-2SRC2; nuclear receptor coactivator 2; TIF2; TIF2hTIF2; Transcriptional intermediary factor 2
Mass (kDA):
159.157 kDA
Human | |
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Location: | 8q13.3 |
Sequence: | 8; NC_000008.11 (70109770..70405390, complement) |
Nucleus.
PMID: 8670870 by Voegel J.J., et al. TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors.
PMID: 9558366 by Carapeti M., et al. A novel fusion between MOZ and the nuclear receptor coactivator TIF2 in acute myeloid leukemia.