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- Table of Contents
, No Gclids
Nucleolin Antibodies
AND NCL ELISA kits, Nucleolin Proteins
Many biological assays use antibodies to detect Nucleolin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Nucleolin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Nucleolin antibodies...
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NCL Infographic by Boster Bio
All NCL Products
Product
Figures
Specificity
Applications
Price
Human, Monkey, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00228-1
100 μg/vial
Cat # A00228-1
100 μg/vial
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M00228-3
100 μl/vial
Cat # M00228-3
100 μl/vial
NCL Overview
Facts about Nucleolin.
Nucleolin (NCL)
Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles.
It induces chromatin decondensation by binding to histone H1. It's thought to play a part in pre-rRNA transcription and ribosome assembly.
Gene Information
| Human | |
|---|---|
| Gene Name: | NCL |
| Uniprot: | P19338 |
| Entrez: | 4691 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
C23; FLJ45706; FLJ59041; nucleolin; Protein C23
Molecular Weight
Mass (kDA):
76.614 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q37.1 |
| Sequence: | 2; NC_000002.12 (231453531..231464484, complement) |
Subcellular Localizations
Nucleus, nucleolus. Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Diseases
- Neuronal Ceroid-lipofuscinoses
- Neurodegenerative Disorders
- Juvenile Neuronal Ceroid Lipfuscinosis
- Nerve Degeneration
- Lysosomal Storage Diseases
- Epilepsy
- Late-infantile Neuronal Ceroid Lipfuscinosis
- Atrophy
- Infantile Neuronal Ceroid Lipofuscinosis
- Blind Vision
- Nervousness
Interacting Proteins
- Ankrd1
- ARFGEF1
- ARRB1
- ARRB2
- COL18A1
- MDM2
- MYH9
- PA2G4
- PAX8
- RHOA
Pathways
- Pathogenesis
- Localization
- Cell Death
- Transport
- Aging
- Proteolysis
- Glycosylation
- Innervation
- Translation
- Angiogenesis
- Cell Proliferation
- Conjugation
- Autophagy
PTMs
- Cleavage
- Glycosylation
- Phosphorylation
- Methylation
- Biotinylation
Research Areas
- Chromatin Research
- DNA replication, Transcription, Translation and Splicing
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NCL
bosterbio.com/bosterbio-gene-info-cards/NCL
References
PMID: 2737305 by Srivastava M., et al. Cloning and sequencing of the human nucleolin cDNA.
PMID: 2394707 by Srivastava M., et al. Genomic organization and chromosomal localization of the human nucleolin gene.