NCKIPSD Antibodies

AND NCKIPSD ELISA kits, NCKIPSD Proteins

Many biological assays use antibodies to detect NCKIPSD, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NCKIPSD in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NCKIPSD antibodies...

We validate the specificity of these antibodies to NCKIPSD by testing them on tissues known to express NCKIPSD positively and negatively. Browse below to find the NCKIPSD antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NCKIPSD Infographic by Boster Bio

All NCKIPSD Products

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Product

Figures

Specificity

Applications

Price

Anti-SPN90 NCKIPSD Antibody

Human, Mouse

ELISA, WB

$380
Cat # A07992
100ul

NCKIPSD (NM_184231) Human Over-expression Lysate

Human

$628
Cat # LS051517
100 µg

NCKIPSD Overview

Facts about NCK-interacting protein with SH3 domain.

NCKIPSD 3D structure. Source: alphafold

NCK-interacting protein with SH3 domain (NCKIPSD)

Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo (By similarity).

In vitro, stimulates N-WASP- triggered ARP2/3 complex activation in the absence of CDC42 (By similarity). May play an important role in the upkeep of sarcomeres and/or at the assembly of myofibrils into sarcomeres.

Gene Information

Human
Gene Name:	NCKIPSD
Uniprot:	Q9NZQ3
Entrez:	51517

Family

Belongs to:

No superfamily

Alternative Names

54 kDa vimentin-interacting protein; 90 kDa SH3 protein interacting with Nck; AF3p21; AF3P21DIP-1; dia interacting protein; Dia-interacting protein 1; diaphanous protein interacting protein; Diaphanous protein-interacting protein; DIP; DIP1; MGC23891; NCK interacting protein with SH3 domain; ORF1; SPIN90VIP54; WASLBP; WASP-interacting SH3-domain protein; WISHSH3 adapter protein SPIN90; Wisk90 kDa

Molecular Weight

Mass (kDA):
78.96 kDA

Genomic Context


Human

Location:	3p21.31
Sequence:	3; NC_000003.12 (48663814..48685941, complement)

Tissue Specificity

Highest expression in heart, brain, skeletal muscle, kidney and liver. Lower levels in placenta, lung, small intestine and leukocytes. Weak expression in colon, thymus and spleen.

Subcellular Localizations

Nucleus. Colocalizes with DRF1 at membrane ruffles, and with Nck at Z-disks in mature cardiac myocytes.

Diseases

Wiskott-aldrich Syndrome
Therapy-related Leukemia
Tissue Adhesions
Leukemia
Immunologic Deficiency Syndromes
Neoplasms
Acute Monocytic Leukemia
Stomach Neoplasms
Neoplasm Metastasis
Melanoma
Neoplasms, Second Primary
M5b Acute Differentiated Monocytic Leukemia

Glioma
Hypoxia
Tumor Angiogenesis
Malignant Neoplasms
Therapy-related Acute Myeloid Leukemia
Aids-associated Nephropathy

Interacting Proteins

BAIAP2
FYN
Pacsin1
Pacsin2
PSMD9

SORBS3

Pathways

Cell Motility
Cell Adhesion
Cell Migration
Endocytosis
Clathrin-mediated Endocytosis
Localization
Tube Formation
Synaptic Transmission
Cytokinesis
Synaptic Vesicle Endocytosis
Phagocytosis

Cellular Localization
Cell Growth
Angiogenesis
Exocytosis
Viral Replication

PTMs

Phosphorylation

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NCKIPSD

References

PMID: 10648423 by Sano K., et al. Novel SH3 protein encoded by the AF3p21 gene is fused to the mixed lineage leukemia protein in a therapy-related leukemia with t(3;11)(p21;q23).

PMID: 10619843 by de Bernard M., et al. The VacA toxin of Helicobacter pylori identifies a new intermediate filament-interacting protein.