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- Table of Contents
Facts about Nuclear cap-binding protein subunit 1.
The CBC complex is vital for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs.
Human | |
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Gene Name: | NCBP1 |
Uniprot: | Q09161 |
Entrez: | 4686 |
Belongs to: |
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NCBP1 family |
CBP80nuclear cap binding protein subunit 1, 80kD; NCBP 80 kDa subunit; NCBPMGC2087; nuclear cap binding protein subunit 1, 80kDa; nuclear cap-binding protein subunit 1,80 kDa nuclear cap-binding protein; Sto1
Mass (kDA):
91.839 kDA
Human | |
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Location: | 9q22.33 |
Sequence: | 9; NC_000009.12 (97633423..97673748) |
Nucleus. Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
PMID: 8069914 by Izaurralde E., et al. A nuclear cap binding protein complex involved in pre-mRNA splicing.
PMID: 7937105 by Kataoka N., et al. Cloning of a complementary DNA encoding an 80 kilodalton nuclear cap binding protein.