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NCAPD2 Antibodies
AND NCAPD2 ELISA kits, NCAPD2 Proteins
Many biological assays use antibodies to detect NCAPD2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NCAPD2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NCAPD2 antibodies...
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NCAPD2 Overview
Facts about Condensin complex subunit 1.
Condensin complex subunit 1 (NCAPD2)
The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May aim the condensin complex to DNA via its C-terminal domain (PubMed:11136719).
May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin- mediated compaction probably increases tension in catenated sister chromatids, providing directionality for type II topoisomerase- mediated strand exchanges toward chromatid decatenation.
Gene Information
| Human | |
|---|---|
| Gene Name: | NCAPD2 |
| Uniprot: | Q15021 |
| Entrez: | 9918 |
Family
| Belongs to: |
|---|
| CND1 (condensin subunit 1) family |
Alternative Names
CAPD2; CAP-D2; Chromosome condensation-related SMC-associated protein 1; Chromosome-associated protein D2; CNAP1XCAP-D2 homolog; hCAP-D2condensin complex subunit 1; KIAA0159chromosome condensation related SMC associated protein 1; Non-SMC condensin I complex subunit D2; non-SMC condensin I complex, subunit D2
Molecular Weight
Mass (kDA):
157.182 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12p13.31 |
| Sequence: | 12; NC_000012.12 (6494102..6531955) |
Subcellular Localizations
Nucleus. Cytoplasm. Chromosome. In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase
Diseases
- Alzheimer's Disease
- Adenocarcinoma
- Malignant Neoplasms
- Ovarian Cysts
- Malignant Neoplasm Of Ovary
- Inflammation
- Epithelial Ovarian Cancer
- Ovarian Neoplasm
Interacting Proteins
- NCAPH
Pathways
- Cell Cycle
- Mitosis
- Dna Repair
- Dna Methylation
- Chromosome Separation
- Ovulation
- Chromosome Segregation
- Proestrus
- Methylation
- Centrosome Separation
PTMs
Research Areas
- Cell Cycle and Replication
- Core ESC-Like Genes
- Mitotic Regulators
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NCAPD2
bosterbio.com/bosterbio-gene-info-cards/NCAPD2
References
PMID: 10958694 by Schmiesing J.A., et al. A human condensin complex containing hCAP-C-hCAP-E and CNAP1, a homolog of Xenopus XCAP-D2, colocalizes with phosphorylated histone H3 during the early stage of mitotic chromosome condensation.
PMID: 11136719 by Kimura K., et al. Chromosome condensation by a human condensin complex in Xenopus egg extracts.