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SEC16A Antibodies
AND SEC16A ELISA kits, SEC16A Proteins
Many biological assays use antibodies to detect SEC16A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SEC16A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SEC16A antibodies...
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SEC16A Overview
Facts about Protein transport protein Sec16A.
Protein transport protein Sec16A (SEC16A)
Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SAR1A-GTP- dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES.
Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17192411, PubMed:17005010, PubMed:17428803, PubMed:21768384, PubMed:22355596). Mediates the recruitment of MIA3/TANGO to ERES (PubMed:28442536).
Gene Information
| Human | |
|---|---|
| Gene Name: | SEC16A |
| Uniprot: | O15027 |
| Entrez: | 9919 |
Family
| Belongs to: |
|---|
| SEC16 family |
Alternative Names
FLJ26737; KIAA0310RP11-413M3.10; p250protein SEC16 homolog A; SEC16 homolog A (S. cerevisiae); SEC16 homolog A; SEC16; SEC16Lprotein transport protein Sec16A
Molecular Weight
Mass (kDA):
251.894 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9q34.3 |
| Sequence: | 9; NC_000009.12 (136440096..136484552, complement) |
Tissue Specificity
Ubiquitous. Expressed at higher levels in the pancreas.
Subcellular Localizations
Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Cytoplasm, perinuclear region. Cytoplasm, cytosol. Microsome membrane. SAR1A activity is required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation (PubMed:17192411). Localizes to endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). MIA3 and LRRK2 are required for its proper localization to ERES (PubMed:25201882, PubMed:28442536, PubMed:19638414, PubMed:17428803, PubMed:22355
Diseases
- Virus Diseases
- Poliomyelitis
- Innate Immune Response
Interacting Proteins
- DOCK7
- LRRK2
- NBEAL2
Pathways
- Transport
- Localization
- Secretory Pathway
- Protein Transport
- Telophase
- Mitosis
- Metaphase
- Exit From Mitosis
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SEC16A
bosterbio.com/bosterbio-gene-info-cards/SEC16A
References
PMID: 17192411 by Bhattacharyya D., et al. Two mammalian Sec16 homologues have nonredundant functions in endoplasmic reticulum (ER) export and transitional ER organization.
PMID: 17005010 by Watson P., et al. Sec16 defines endoplasmic reticulum exit sites and is required for secretory cargo export in mammalian cells.