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- Table of Contents
Facts about Nanos homolog 2.
Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the upkeep of the spermatogonial stem cell population.
Human | |
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Gene Name: | NANOS2 |
Uniprot: | P60321 |
Entrez: | 339345 |
Belongs to: |
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nanos family |
nanos homolog 2 (Drosophila); nanos homolog 2; Nanos2; NOS2NOS-2
Mass (kDA):
15.132 kDA
Human | |
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Location: | 19q13.32 |
Sequence: | 19; NC_000019.10 (45913214..45914778, complement) |
Testis and ovary. Expression found in several spermatogenic stages: in cells on the periphery of the tubules which could correspond to spermatogonia, in spermatocytes and in round spermatids (at protein level).
Cytoplasm. Cytoplasm, P-body. Cytoplasm, perinuclear region. Localizes at P-bodies during gonocyte development (By similarity). More abundant in perinuclear region of the cytoplasm of the germ cells of the adult testis.
PMID: 19168545 by Kusz K.M., et al. The highly conserved NANOS2 protein: testis-specific expression and significance for the human male reproduction.
PMID: 21421998 by Julaton V.T., et al. NANOS3 function in human germ cell development.