SOSS complex subunit B1 (Nabp2)

Component of the SOSS complicated, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. From the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines.

The SOSS complex associates with DNA lesions and affects diverse endpoints from the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways (By similarity).