Methyltransferase N6AMT1 Antibodies

AND N6AMT1 ELISA kits, Methyltransferase N6AMT1 Proteins

Many biological assays use antibodies to detect Methyltransferase N6AMT1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Methyltransferase N6AMT1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Methyltransferase N6AMT1 antibodies...

We validate the specificity of these antibodies to Methyltransferase N6AMT1 by testing them on tissues known to express N6AMT1 positively and negatively. Browse below to find the N6AMT1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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N6AMT1 Infographic by Boster Bio

All N6AMT1 Products

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Specificity

Applications

Price

Anti-Methyltransferase N6AMT1 N6AMT1 Antibody

Human, Mouse, Rat

IF, ICC, WB

$405
Cat # A10854
100ul

Human N6AMT1 Recombinant Protein

SDS-PAGE

$250
Cat # PROTQ9Y5N5
Starting from 10ug

HEMK2 (N6AMT1) (NM_182749) Human Over-expression Lysate

Human

$628
Cat # LS029104
100 µg

N6AMT1 Overview

Facts about Methyltransferase N6AMT1.

N6AMT1 3D structure. Source: alphafold

Methyltransferase N6AMT1 (N6AMT1)

Methyltransferase that could methylate both proteins and DNA, and to a lesser degree, arsenic (PubMed:18539146, PubMed:21193388, PubMed:30017583). Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5-methylation of Glu residue of proteins with a Gly-Gln-Xaa-Xaa-Xaa-Arg motif (PubMed:18539146) (By similarity).

Methylates ETF1 on'Gln-185'; ETF1 needs to be complexed to ERF3 in its GTP-bound form to be economically methylated (PubMed:18539146, PubMed:20606008). Also functions as a N(6)-adenine-specific DNA methyltransferase by mediating methylation of DNA on the 6th position of adenine (N(6)- methyladenosine) (PubMed:30017583).

Gene Information

Human
Gene Name:	N6AMT1
Uniprot:	Q9Y5N5
Entrez:	29104

Family

Belongs to:

eukaryotic/archaeal PrmC-related family

Alternative Names

C21orf127; chromosome 21 open reading frame 127; EC 2.1.1.-; HemK methyltransferase family member 2; HEMK2; m.HsaHemK2P; MGC19995; MTQ2; N(6)-adenine-specific DNA methyltransferase 1; N-6 adenine-specific DNA methyltransferase 1 (putative); N6AMT; N6-DNA-methyltransferase; PRED28

Molecular Weight

Mass (kDA):
22.957 kDA

Genomic Context


Human

Location:	21q21.3
Sequence:	21; NC_000021.9 (28439661..28885373, complement)

Tissue Specificity

Widely expressed, with highest expression in parathyroid and pituitary glands, followed by adrenal gland and kidney, and lowest expression in leukocytes and mammary gland.

Subcellular Localizations

Nucleus.

Pathways

Methylation
Translation

PTMs

Methylation

Oxidation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/N6AMT1

References

PMID: 18539146 by Figaro S., et al. HemK2 protein, encoded on human chromosome 21, methylates translation termination factor eRF1.

PMID: 20606008 by Liu P., et al. Deficiency in a glutamine-specific methyltransferase for release factor causes mouse embryonic lethality.