Myosin-7 Antibodies

Myosin-7 (MYH7)

Myosins are actin-based motor molecules with ATPase activity necessary for muscle contraction. Types regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile component of skeletal and cardiac muscle.

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Gene Information

Human
Gene Name:	MYH7
Uniprot:	P12883
Entrez:	4625

Family

Belongs to:
TRAFAC class myosin-kinesin ATPase superfamily

Alternative Names

cardiac muscle beta isoform; CMD1S; CMD1SMGC138376; CMH1; DKFZp451F047; MGC138378; MPD1; MYH7; MYHCB; MyHC-beta; myhc-slow; myopathy, distal 1; myosin heavy chain (AA 1-96); myosin, heavy chain 7, cardiac muscle, beta; myosin, heavy polypeptide 7, cardiac muscle, beta; Myosin-7; rhabdomyosarcoma antigen MU-RMS-40.7A; SPMD; SPMM

Molecular Weight

Mass (kDA):
223.097 kDA

Genomic Context

Human
Location:	14q11.2
Sequence:	14; NC_000014.9 (23412740..23435677, complement)

Tissue Specificity

Both wild type and variant Gln-403 are detected in skeletal muscle (at protein level).

Subcellular Localizations

Cytoplasm, myofibril. Cytoplasm, myofibril, sarcomere. Thick filaments of the myofibrils.

Diseases

• Cardiomyopathies
• Hypertrophy
• Hypertrophic Cardiomyopathy
• Cardiomyopathy, Hypertrophic, Familial
• Myopathy
• Sudden Cardiac Death
• Cardiomyopathy, Dilated
• Cardiac Death
• Heart Failure
• Left Ventricular Hypertrophy
• Cardiomyopathy, Familial Idiopathic
• Distal Muscular Dystrophies

• Sudden Death
• Heart Diseases
• Weakness
• Cardiac Hypertrophy
• Muscle Weakness
• Malignant Paraganglionic Neoplasm
• Hereditary Diseases

Interacting Proteins

• KXD1
• LRRC39

Pathways

• Pathogenesis
• Localization
• Transport
• Mrna Splicing
• Translation
• Metaphase
• Innervation
• Cell Migration
• Fertilization
• Regulation Of Gene Expression
• Cardiac Conduction
• Cell Motility
• Cell Differentiation

• Lipid Storage
• Myoblast Differentiation
• Chromatin Remodeling
• Myoblast Fusion
• Response To Stress
• Myosin Filament Assembly
• Energy Homeostasis

PTMs

• Phosphorylation

• Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MYH7

Best Uses Of The MYH7 Marker In Your Boster Bio

This article will give you a Best Practices Guide for the MYH7 marker that you have in your Boster Bio. In this article, we'll examine the optimization process and troubleshooting. This guide will help you get the highest quality results. Also, read the troubleshooting manuals and learn how to optimize your experiments. These guides will help you understand what to look for when troubleshooting and the best way to avoid these issues altogether.

Optimization

If you're a biologist, there are many questions that you might have. Boster Bio's optimization guides and tips can assist you in answering many of your questions and optimize your studies to get the best results. Every researcher will run into problems at some point or another. You can eliminate many of these causes by using proper controls. Troubleshooting guides are invaluable in identifying the root of issues and aiding you get rid of them.