Myeloid-derived growth factor (Mydgf)

Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and elastic angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway.

Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway. .