MRC1 Antibodies

Macrophage mannose receptor 1 (MRC1)

Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains.

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Gene Information

Human
Gene Name:	MRC1
Uniprot:	P22897
Entrez:	4360

Family

Belongs to:
No superfamily

Alternative Names

CD206; CLEC13D; CLEC13Dmacrophage mannose receptor 1; C-type lectin domain family 13 member D; mannose receptor, C type 1; MMR; MMRCD206 antigen; MRC1

Molecular Weight

Mass (kDA):
166.012 kDA

Genomic Context

Human
Location:	10p12.33
Sequence:	10; NC_000010.11 (17809348..17911164)

Subcellular Localizations

Endosome membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein.

Diseases

• Genomic Instability
• Neoplasms
• Physiological Stress
• Tumor Angiogenesis
• Telomere Shortening
• Pathologic Neovascularization
• Inflammation
• Genotoxic Stress
• Leprosy
• Trinucleotide Repeat Expansion
• Ataxia
• Chromosome Breakage

• Psoriasis
• Filariasis
• Asthma
• Infective Disorder
• Cell Transformation, Neoplastic
• Leprosy, Paucibacillary
• Leprosy, Multibacillary

Pathways

• Dna Replication
• Dna Damage Checkpoint
• S Phase
• Cell Cycle
• Dna Replication Checkpoint
• Dna Repair
• Cell Cycle Arrest
• Sister Chromatid Cohesion
• Mitosis
• Cell Proliferation
• Immune Response
• Hypersensitivity
• Meiosis

• Angiogenesis
• Macrophage Activation
• Replication Fork Protection
• Pathogenesis
• Replication Fork Arrest
• Localization
• Senescence

PTMs

• Phosphorylation
• Acetylation
• Sumoylation

• Reduction
• Deacetylation
• Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MRC1

Boster Bio: Best Uses Of The MRC1 Marker

This article will provide you with information about the company's history and the best uses for its MRC1 marker. You will also learn about Steven Boster, the creator of the marker, and the advantages of using it in your research. Also, you will gain an overview of the MRC1 monoclonal antibody. This antibody can be used to test samples of special species or to test applications. Additionally, you will learn a little bit about the MRC1 monoclonal antibodies.

Boster Bio's Marker MRC1

Many companies offer anti MRC1 antibodies. These antibodies target the mannose receptor C type protein (also called CD206, CLEC13D or NIMA Kinase 2, akin to NIMA) and could have orthologs in yeasts monkeys, canines, and monkeys. These antibodies detect MRC1 protein in cells. They could also detect other proteins like CD163, which may be expressed on different cells.

Steven Boster's history

Steven Boster, a smart businessman, earned a nickname in the lab due to his ability to develop hundreds of primary antibodies. After several years, he grew his company to become the largest catalog antibody company in China. Steven Boster also created PicoKine(tm) a proprietary ELISA platform in the late 1990s. This patent-pending technology allows for high sensitivity ELISA kits which are now available to researchers and biotech companies all over the world.

Overview of the monoclonal anti-body MRC1.

Many tissues and organs have high levels of the MRC1 gene. It is also found overexpressed on monocytes and dendritic cells, and is thought to play a role in adaptive and innate immune. The expression of MRC1 is evident by immunohistology on tissue macrophages as well as dendritic cell tissues. The antibody prevents the binding of glycoproteins and MR to the antibody, thereby labeling the cells.

This monoclonal antibody targets C-type family of lectins, 13 members D (CLEC13DL). It recognizes the mannose receptor. This type of receptor is expressed weakly at the cell surface, however the antibody may enhance staining after membrane permeation. The anti-mouse rat CD206 antibody clone MR5D3 was demonstrated to be effective in Western Blot and other immunohistochemical tests.

The mouse monoclonal antibody to recombinant human MRC1 is raised. This protein is located on the surface of many mammals. This monoclonal antibody can be diminished to a concentration which is suitable for your research. When making a monoclonal antibodies, ensure it is diluted to the working dilution of 0.02 percent sodium azide. The antibody is safe to use when it is diluted to 100 ug/ml.

The MRC1 monoclonal antibody targets macrophages M1 which are known to trigger and sustain inflammation throughout the body. The use of these antibodies can dramatically improve health by reducing activity of these immune cells. In actual fact, it is the most effective antigen against M1 macrophages. These cells are found in the bloodstream and play a crucial role in maintaining inflammation within the body.