MPZL1 Antibodies

AND MPZL1 ELISA kits, MPZL1 Proteins

Many biological assays use antibodies to detect MPZL1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MPZL1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MPZL1 antibodies...

We validate the specificity of these antibodies to MPZL1 by testing them on tissues known to express MPZL1 positively and negatively. Browse below to find the MPZL1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MPZL1 Infographic by Boster Bio

All MPZL1 Products

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Product

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Specificity

Applications

Price

MPZL (MPZL1) (NM_003953) Human Recombinant Protein

$813
Cat # PROTO95297
20 µg

MPZL (MPZL1) (NM_003953) Human Over-expression Lysate

Human

$628
Cat # LS009019
100 µg

Anti-MPZL1 Antibody Picoband®

Human

ELISA, WB

$370
Cat # A06667-1
100 µg/vial

MPZL1 Overview

Facts about Myelin protein zero-like protein 1.

MPZL1 3D structure. Source: alphafold

Myelin protein zero-like protein 1 (MPZL1)

Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2.

Is a significant receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine- protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA.

Gene Information

Human
Gene Name:	MPZL1
Uniprot:	O95297
Entrez:	9019

Family

Belongs to:

myelin P0 protein family

Alternative Names

FLJ21047; immunoglobulin family transmembrane protein; MPZL1b; myelin protein zero-like 1; myelin protein zero-like protein 1; protein zero related; Protein zero-related; PZR1b; PZRb; PZRPZRa

Molecular Weight

Mass (kDA):
29.082 kDA

Genomic Context


Human

Location:	1q24.2
Sequence:	1; NC_000001.11 (167721982..167791919)

Tissue Specificity

Widely expressed with highest levels in heart, placenta, kidney and pancreas. Isoform 3 is relatively abundant in hematopoietic tissues and fetal liver. Isoform 1 and isoform 3 are expressed in CD14- PB monocytes and pre-B cell progenitors. Isoform 3 appears to be the major isoform in CD34- promyelocytic and promonocytic cells. During differentiation in monocytic cells, the expression level of isoform 3 decreases and that of isoform 1 increases. Isoform 1 is prominent in stromal cells and, to a lesser extent, in umbilical vein endothelial cells and erythroid progenitors. Isoform 2 is expressed in a erythroid progenitor cell line.

Subcellular Localizations

Membrane; Single-pass type I membrane protein.

Diseases

Charcot-marie-tooth Disease
Demyelinating Diseases
Noonan Syndrome
Polyneuropathy
Neurological Signs And Symptoms
Muscle Oedema
Adipose Tissue Atrophy
Schizophrenia
Talipes Cavus
Atrophy
Periodic Paralysis (finding)

Edema
Charcot-marie-tooth Disease, Type 2j
Corneal Diseases
Peripheral Neuropathy
Familial Periodic Paralysis
Adie Syndrome

Interacting Proteins

PTPN11

Pathways

Hyperphosphorylation
Cell Migration
Blastocyst Formation
Cell Motility
Pathogenesis

PTMs

Phosphorylation

Dephosphorylation

Research Areas

Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MPZL1

References

PMID: 9792637 by Zhao Z.J., et al. Purification and cloning of PZR, a binding protein and putative physiological substrate of tyrosine phosphatase SHP-2.

PMID: 12075424 by Tang D.S., et al. Cloning of human myelin protein zero-like genes by bioinformatics strategy.