Hepatocyte growth factor receptor (MET)

Receptor tyrosine kinase that transduces signals from the extracellular matrix to the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival.

Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that offers docking sites for downstream signaling molecules. After activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1.