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- Table of Contents
Facts about Mesoderm-specific transcript homolog protein.
Human | |
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Gene Name: | MEST |
Uniprot: | Q5EB52 |
Entrez: | 4232 |
Belongs to: |
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AB hydrolase superfamily |
DKFZp686L18234; EC 3.-; mesoderm specific transcript (mouse) homolog; mesoderm specific transcript homolog (mouse); mesoderm-specific transcript homolog protein; MGC111102; MGC8703; paternally expressed gene 1; PEG1Paternally-expressed gene 1 protein
Mass (kDA):
38.83 kDA
Human | |
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Location: | 7q32.2 |
Sequence: | 7; NC_000007.14 (130486175..130506465) |
Highly expressed in hydatidiform moles, but barely expressed in dermoid cysts. Biallelic expression is detected in blood lymphocytes. Seems to imprinted in an isoform- specific manner rather than in a tissue-specific manner in lymphocytes. Isoform 1 is expressed only from the paternal allele. Isoform 2 is expressed from both the paternal allele and the maternal allele.
Endoplasmic reticulum membrane; Multi-pass membrane protein.
PMID: 8884280 by Nishita Y., et al. Genomic imprinting and chromosomal localization of the human MEST gene.
PMID: 9192843 by Riesewijk A.M., et al. Monoallelic expression of human PEG1/MEST is paralleled by parent- specific methylation in fetuses.