MZB1 Antibodies

AND MZB1 ELISA kits, MZB1 Proteins

Many biological assays use antibodies to detect MZB1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MZB1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MZB1 antibodies...

We validate the specificity of these antibodies to MZB1 by testing them on tissues known to express MZB1 positively and negatively. Browse below to find the MZB1 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MZB1 Infographic by Boster Bio

All MZB1 Products

Product

Figures

Specificity

Applications

Price

Anti-PACAP MZB1 Antibody

6 Q&As

Human

IHC

$399
Cat # A08281
100μl

Human MZB1 Recombinant Protein

SDS-PAGE

$250
Cat # PROTQ8WU39
Starting from 20ug

Proapoptotic Caspase Adaptor Protein (MZB1) (NM_016459) Human Over-expression Lysate

Human

$628
Cat # LS051237
100 µg

Anti-MZB1 Antibody Picoband™

Human

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A08281-1
100 µg/vial

MZB1 Overview

Facts about Marginal zone B- and B1-cell-specific protein.

MZB1 3D structure. Source: alphafold

Marginal zone B- and B1-cell-specific protein (MZB1)

Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM secretion and assembly. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity).

Isoform 2 may be involved in regulation of apoptosis. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation.

Gene Information

Human
Gene Name:	MZB1
Uniprot:	Q8WU39
Entrez:	51237

Family

Belongs to:

MZB1 family

Alternative Names

caspase-2 binding protein; FLJ32987; HSPC190; marginal zone B and B1 cell-specific protein; MGC29506; PACAP; pERp1; plasma cell-induced ER protein 1; plasma cell-induced resident endoplasmic reticulum protein; Plasma cell-induced resident ER protein; Proapoptotic caspase adapter protein; proapoptotic caspase adaptor protein

Molecular Weight

Mass (kDA):
20.694 kDA

Genomic Context


Human

Location:	5q31.2
Sequence:	5; NC_000005.10 (139387467..139389913, complement)

Tissue Specificity

Widely expressed with highest levels in adult brain, small intestine and lymphoid tissues such as thymus and spleen. Expression is frequently lower in intestinal-type gastric cancer. In obese patients, more abundant in omental than in subcutaneous fat.

Subcellular Localizations

[Isoform 1]: Endoplasmic reticulum lumen. Secreted.; [Isoform 2]: Cytoplasm. Diffuse granular localization in the cytoplasm surrounding the nucleus (PubMed:11350957).

Diseases

Cell Transformation, Neoplastic
Neoplasms
Liver Carcinoma
Liver Neoplasms
Tissue Adhesions
Hepatocarcinogenesis

Carcinoma

Pathways

Cell Adhesion
Methylation
Cell Proliferation
Dna Hypermethylation
Integrin Activation
Localization

Secretion

PTMs

Methylation

Research Areas

Apoptosis
Caspases

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MZB1

References

PMID: 11350957 by Bonfoco E., et al. Characterization of a novel proapoptotic caspase-2- and caspase-9- binding protein.

PMID: 19805157 by Shimizu Y., et al. pERp1 is significantly up-regulated during plasma cell differentiation and contributes to the oxidative folding of immunoglobulin.