Unconventional myosin-XV Antibodies

AND MYO15A ELISA kits, Unconventional myosin-XV Proteins

Many biological assays use antibodies to detect Unconventional myosin-XV, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Unconventional myosin-XV in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Unconventional myosin-XV antibodies...

We validate the specificity of these antibodies to Unconventional myosin-XV by testing them on tissues known to express MYO15A positively and negatively. Browse below to find the MYO15A antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MYO15A Infographic by Boster Bio

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Anti-MYO15 Antibody

Human, Mouse

IHC

$380
Cat # A05654
100ul

MYO15A Overview

Facts about Unconventional myosin-XV.

Unconventional myosin-XV (MYO15A)

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements.

Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Required for the arrangement of stereocilia in mature hair bundles (By similarity).

Gene Information

Human
Gene Name:	MYO15A
Uniprot:	Q9UKN7
Entrez:	51168

Family

Belongs to:

TRAFAC class myosin-kinesin ATPase superfamily

Alternative Names

DFNB3; DKFZp686N18198; FLJ17274; FLJ31311; MYO15; myosin XVA; myosin-XV; Unconventional myosin-15

Molecular Weight

Mass (kDA):
395.293 kDA

Genomic Context


Human

Location:	17p11.2
Sequence:	17; NC_000017.11 (18108756..18180244)

Tissue Specificity

Highly expressed in pituitary. Also expressed at lower levels in adult brain, kidney, liver, lung, pancreas, placenta and skeletal muscle. Not expressed in brain. In the pituitary, highly expressed in anterior gland cells.

Subcellular Localizations

Cell projection, stereocilium. Cytoplasm, cytoskeleton. Localizes to stereocilium tips in cochlear and vestibular hair cells.

Diseases

Complete Hearing Loss
Sensorineural Hearing Loss (disorder)
Pituitary Diseases
Endocrine Gland Neoplasms
Circling Gait
Deafness Congenital
Neoplasms
Smith-magenis Syndrome
Deaf Mutism
Adenoma
Disease Of Adrenal Medulla
Retinal Degeneration

Gastrointestinal Neoplasms
De Novo Mutation
Malignant Neoplasms
Pancreatic Neoplasm
Pituitary Neoplasms
Presbycusis
Nervous System Neoplasms

Pathways

Localization
Secretion
Cell Death
Signal Transmission
Cell Development
Muscle Contraction

Hormone Secretion

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MYO15A

References

PMID: 9603736 by Wang A., et al. Association of unconventional myosin MYO15 mutations with human nonsyndromic deafness DFNB3.

PMID: 10552926 by Liang Y., et al. Characterization of the human and mouse unconventional myosin XV genes responsible for hereditary deafness DFNB3 and shaker 2.