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HSD17B11 Antibodies
AND HSD17B11 ELISA kits, HSD17B11 Proteins
Many biological assays use antibodies to detect HSD17B11, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HSD17B11 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HSD17B11 antibodies...
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HSD17B11 Overview
Facts about Estradiol 17-beta-dehydrogenase 11.
Estradiol 17-beta-dehydrogenase 11 (HSD17B11)
Can convert androstan-3-alpha,17-beta-diol (3-alpha- diol) into androsterone in vitro, suggesting that it might participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it.
Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a small activity toward testosterone to A-dione. Tumor- associated antigen in cutaneous T-cell lymphoma.
Gene Information
| Human | |
|---|---|
| Gene Name: | HSD17B11 |
| Uniprot: | Q8NBQ5 |
| Entrez: | 51170 |
Family
| Belongs to: |
|---|
| short-chain dehydrogenases/reductases (SDR) family |
Alternative Names
17betaHSD11; 17betaHSDXI; 17-beta-hydroxysteroid dehydrogenase 11; 17-beta-hydroxysteroid dehydrogenase type XI; 17-beta-hydroxysteroid dehydrogenase XI; 17bHSD11; CTCL-associated antigen HD-CL-03; dehydrogenase/reductase (SDR family) member 8; DHRS8; EC 1.1.1; EC 1.1.1.62; hydroxysteroid (17-beta) dehydrogenase 11; member 2,17-beta-HSD 11; PAN1BRETSDR2,17-BETA-HSD11; retSDR2; RetSDR2,17-BETA-HSDXI; SDR16C2,17BHSD11; T-cell lymphoma-associated antigen HD-CL-03,17-beta-HSD XI
Molecular Weight
Mass (kDA):
32.936 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4q22.1 |
| Sequence: | 4; NC_000004.12 (87336515..87391252, complement) |
Tissue Specificity
Present at high level in steroidogenic cells such as syncytiotrophoblasts, sebaceous gland, Leydig cells, and granulosa cells of the dominant follicle and corpus luteum. In lung, it is detected in the ciliated epithelium and in acini of adult trachea, in bronchioles, but not in alveoli. In the eye, it is detected in the nonpigmented epithelium of the ciliary body and, at lower level, in the inner nuclear layer of the retina (at protein level). Widely expressed. Highly expressed in retina, pancreas, kidney, liver, lung, adrenal, small intestine, ovary and heart.
Subcellular Localizations
Endoplasmic reticulum. Lipid droplet. Redistributed from the endoplasmic reticulum to lipids droplets in the cell upon induction of lipids droplet formation.
Diseases
- Malignant Neoplasms
- Malignant Neoplasm Of Prostate
- Prostatic Neoplasms
- Cell Invasion
- Lung Neoplasms
- Liver Carcinoma
- Tumors Of Adrenal Cortex
- Neoplasm Invasiveness
- Malignant Neoplasm Of Lung
Pathways
- Cell Growth
- Pathogenesis
- Conjugation
Research Areas
- Lipid and Metabolism
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HSD17B11
bosterbio.com/bosterbio-gene-info-cards/HSD17B11
References
PMID: 10800688 by Haeseleer F., et al. Short-chain dehydrogenases/reductases in retina.
PMID: 14996095 by Hartmann T.B., et al. SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma.