This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Unconventional myosin-X.
MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments.
Human | |
---|---|
Gene Name: | MYO10 |
Uniprot: | Q9HD67 |
Entrez: | 4651 |
Belongs to: |
---|
TRAFAC class myosin-kinesin ATPase superfamily |
FLJ10639; FLJ21066; FLJ22268; KIAA0799FLJ43256; MGC131988; myosin X; myosin-X; Unconventional myosin-10
Mass (kDA):
237.347 kDA
Human | |
---|---|
Location: | 5p15.1 |
Sequence: | 5; NC_000005.10 (16661907..16936288, complement) |
Ubiquitous.
Cytoplasm, cytosol. Cell projection, lamellipodium. Cell projection, ruffle. Cytoplasm, cytoskeleton. Cell projection, filopodium tip. Cytoplasm, cell cortex. Cell projection, filopodium membrane; Peripheral membrane protein. May be in an inactive, monomeric conformation in the cytosol. Detected in cytoplasmic punctae and in cell projections. Colocalizes with actin fibers. Undergoes forward and rearward movements within filopodia. Interacts with microtubules.
PMID: 10984435 by Berg J.S., et al. Myosin-X, a novel myosin with pleckstrin homology domains, associates with regions of dynamic actin.
PMID: 11278607 by Rogers M.S., et al. The tumor-sensitive calmodulin-like protein is a specific light chain of human unconventional myosin X.