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MYLK Antibodies
AND MYLK ELISA kits, MYLK Proteins
Many biological assays use antibodies to detect MYLK, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MYLK in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MYLK antibodies...
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MYLK Infographic by Boster Bio
All MYLK Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M01697
100 μl
Cat # M01697
100 μl
Anti-Myosin light chain kinase/MYLK Antibody Picoband®
1 Citations 1 Q&As
Human, Mouse, Rat
ELISA, IHC, WB
$370
Cat # A01697-2
100 μg/vial
Cat # A01697-2
100 μg/vial
Human
$628
Cat # LS004638
100 µg
Cat # LS004638
100 µg
MYLK Overview
Facts about Myosin light chain kinase, smooth muscle.
Myosin light chain kinase, smooth muscle (MYLK)
Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity.
Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory reaction (e.
Gene Information
| Human | |
|---|---|
| Gene Name: | MYLK |
| Uniprot: | Q15746 |
| Entrez: | 4638 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
DKFZp686I10125; EC 2.7.11; EC 2.7.11.18; FLJ12216; Kinase-related protein; KRP; light polypeptide kinase; MLCK1; MLCK108; MLCKMLCK210; MSTP083; MYLK1; myosin light chain kinase; smooth muscle myosin light chain kinase; smooth muscle; telokin
Molecular Weight
Mass (kDA):
210.715 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3q21.1 |
| Sequence: | 3; NC_000003.12 (123610049..123884332, complement) |
Tissue Specificity
Smooth muscle and non-muscle isozymes are expressed in a wide variety of adult and fetal tissues and in cultured endothelium with qualitative expression appearing to be neither tissue- nor development-specific. Non-muscle isoform 2 is the dominant splice variant expressed in various tissues. Telokin has been found in a wide variety of adult and fetal tissues. Accumulates in well differentiated enterocytes of the intestinal epithelium in response to tumor necrosis factor (TNF).
Subcellular Localizations
Cytoplasm. Cell projection, lamellipodium. Cleavage furrow. Cytoplasm, cytoskeleton, stress fiber. Localized to stress fibers during interphase and to the cleavage furrow during mitosis.
Diseases
- Lung Injury
- Asthma
- Acute Lung Injury
- Malignant Neoplasms
- Neoplasms
- Systemic Infection
- Inflammation
- Inflammatory Response
- Pneumonia
- Respiratory Distress Syndrome, Adult
- Tissue Adhesions
- Cholangiocarcinoma
Interacting Proteins
- GOPC
- NCK1
Pathways
- Pathogenesis
- Immune Response
- Inflammatory Response
- Smooth Muscle Contraction
- Muscle Contraction
- Diapedesis
- Localization
- Cell Motility
- Cell Adhesion
- Cell Proliferation
- Cell Migration
- Aging
- Dna Repair
PTMs
- Phosphorylation
Research Areas
- Protein Kinase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MYLK
bosterbio.com/bosterbio-gene-info-cards/MYLK
References
PMID: 8575746 by Potier M.-C., et al. The human myosin light chain kinase (MLCK) from hippocampus: cloning, sequencing, expression, and localization to 3qcen-q21.
PMID: 9160829 by Garcia J.G.N., et al. Myosin light chain kinase in endothelium: molecular cloning and regulation.
1 Publications of Boster MYLK Antibodies & ELISA Kits
- PubMed ID: 10.1161/JAHA.120.017094, Extreme Diversity of the Human Vascular Mesenchymal Cell Landscape
*More publications can be found for each product on its corresponding product page