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MYLIP Antibodies
AND MYLIP ELISA kits, MYLIP Proteins
Many biological assays use antibodies to detect MYLIP, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MYLIP in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MYLIP antibodies...
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MYLIP Overview
Facts about E3 ubiquitin-protein ligase MYLIP.
E3 ubiquitin-protein ligase MYLIP (MYLIP)
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Action depends on E2 enzymes of the UBE2D family.
Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol- dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.
Gene Information
| Human | |
|---|---|
| Gene Name: | MYLIP |
| Uniprot: | Q8WY64 |
| Entrez: | 29116 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
band 4.1 superfamily member BZF1; BZF1; cellular modulator of immune recognition (c-MIR); EC 6.3.2.-; Idol; IDOLmyosin regulatory light chain-interacting protein; Inducible degrader of the LDL-receptor; MIRE3 ubiquitin-protein ligase MYLIP; myosin regulatory light chain interacting proteinE3 ubiquitin ligase-inducible degrader of the low density lipoprotein receptor
Molecular Weight
Mass (kDA):
49.91 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6p22.3 |
| Sequence: | 6; NC_000006.12 (16129086..16151015) |
Tissue Specificity
Ubiquitously expressed.
Subcellular Localizations
Cytoplasm. Cell membrane; Peripheral membrane protein.
Diseases
- Cardiovascular Diseases
- Dyslipidemias
- Coronary Artery Disease
- Carcinoma
- Neoplasms
- 5,10-methylenetetrahydrofolate Reductase Deficiency
- Obesity
- Cholangiocarcinoma
- Stenosis
- Hepatitis, Chronic
- Leukemia, Radiation-induced
- Leukemia, T-cell
- Head And Neck Carcinoma
Interacting Proteins
- CNPY2
- DDIT4L
- MIPOL1
- PAX9
- RASSF5
- TSC22D4
Pathways
- Cell Motility
- Localization
- Cellular Localization
- Cholesterol Efflux
- Brain Development
- Immune Response
- Cell Growth
- Endocytosis
PTMs
Research Areas
- Lipid and Metabolism
- Zinc Finger
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MYLIP
bosterbio.com/bosterbio-gene-info-cards/MYLIP
References
PMID: 10593918 by Olsson P.-A., et al. MIR is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth.
PMID: 14550572 by Bornhauser B.C., et al. Functional activities and cellular localization of the ezrin, radixin, moesin (ERM) and RING zinc finger domains in MIR.