MYCBP2 Antibodies

AND MYCBP2 ELISA kits, MYCBP2 Proteins

Many biological assays use antibodies to detect MYCBP2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MYCBP2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MYCBP2 antibodies...

We validate the specificity of these antibodies to MYCBP2 by testing them on tissues known to express MYCBP2 positively and negatively. Browse below to find the MYCBP2 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MYCBP2 Infographic by Boster Bio

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MYCBP2 Overview

Facts about E3 ubiquitin-protein ligase MYCBP2.

E3 ubiquitin-protein ligase MYCBP2 (MYCBP2)

Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues (PubMed:29643511). Reveals esterification activity towards both threonine and serine, with a preference for threonine, and acts through two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates (PubMed:29643511).

Involved in different processes like regulation of neurite outgrowth, synaptic development, synaptogenesis and axon degeneration (By similarity). Required for the formation of major central nervous system axon tracts (By similarity).

Gene Information

Human
Gene Name:	MYCBP2
Uniprot:	O75592
Entrez:	23077

Family

Belongs to:

RING-Cys relay (RCR) family

Alternative Names

DKFZp686M08244; EC 6.3.2.-; FLJ10106; FLJ21646; KIAA0916FLJ13826; MYC binding protein 2; Myc-binding protein 2; Pam/highwire/rpm-1 protein; PAMFLJ21597; probable E3 ubiquitin-protein ligase MYCBP2; Protein associated with Myc

Molecular Weight

Mass (kDA):
513.636 kDA

Genomic Context


Human

Location:	13q22.3
Sequence:	13; NC_000013.11 (77044657..77327098, complement)

Tissue Specificity

Expressed in all tissues examined, expression is exceptionally abundant in brain and thymus. Colocalizes with TSC1 and TSC2 along the neurites and in the growth cones. Highly expressed in peripheral and central neurons. Colocalized with TSC1 in one of the filopodial extensions at the tip of a growth cone.

Subcellular Localizations

Nucleus. Cell projection, axon. Cytoplasm, cytoskeleton. Localizes to axon shafts and associates with microtubule cytoskeleton (By similarity). Translocates to the nucleus following interaction with sumoylated RANGAP1 (PubMed:26304119).