MYB Antibodies

Transcriptional activator Myb (MYB)

Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.

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Gene Information

Human
Gene Name:	MYB
Uniprot:	P10242
Entrez:	4602

Family

Belongs to:
No superfamily

Alternative Names

c-myb protein (140 AA); Cmyb; c-myb; c-myb_CDS; c-myb10A_CDS; c-myb13A_CDS; c-myb14A_CDS; c-myb8B_CDS; efg; Proto-oncogene c-Myb; transcriptional activator Myb; v-myb avian myeloblastosis viral oncogene homolog; v-myb myeloblastosis viral oncogene homolog (avian)

Molecular Weight

Mass (kDA):
72.341 kDA

Genomic Context

Human
Location:	6q23.3
Sequence:	6; NC_000006.12 (135181308..135219172)

Subcellular Localizations

Nucleus.

Diseases

• Neoplasms
• Leukemia
• Malignant Neoplasms
• Cell Transformation, Neoplastic
• Myeloid Leukemia
• Carcinoma
• Physiological Stress
• Malignant Paraganglionic Neoplasm
• Lymphoma
• Melanoma
• Malignant Neoplasm Of Breast
• Mammary Neoplasms
• Dehydration

• Leukemogenesis
• Leukemia, Myelocytic, Acute
• Cytogenetic Abnormality
• Chromosomal Translocation
• Skin Neoplasms
• Melanocytic Nevus
• Acute Erythroblastic Leukemia

Interacting Proteins

• CLTC
• ERC2
• SUMO1
• SUMO2
• TAL1

• ZFC3H1

Pathways

• Cell Cycle
• Localization
• Cell Proliferation
• Pigmentation
• Cell Differentiation
• Pathogenesis
• Transport
• Cell Growth
• Germination
• Cell Development
• Methylation
• Translation
• Cell Death

• Dna Replication
• S Phase
• Cell Fate Determination
• Cell Division
• Gene Silencing
• Regulation Of Gene Expression
• Mitosis

PTMs

• Phosphorylation
• Methylation
• Acetylation
• Cleavage
• Ubiquitination
• Glycosylation
• Nitration
• Oxidation
• Sumoylation

• Reduction
• Demethylation
• Hydroxylation
• Nitrosylation
• Phosphorothioation
• Dephosphorylation
• Prenylation
• Ribosylation
• Biotinylation

• Deacetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MYB

Top 5 Uses Of The MYB Marker Monoclonal Antibody

This article explores the MYB (Anti-Myeloid-Associated Differentiation) Marker Monoclonal Antibody and its uses. It also discusses Safety, Primer Pairs and Clinical Applications. This article is applicable to all scientists around the world. Find out more! Below are the Top 5 Uses of The MYB Marker

Anti-Myeloid-Associated Differentiation Marker (MYADM) Monoclonal Antibody (MYADM)

This monoclonal antibody was specially made for research use. It was developed to identify a specific protein that is linked to myeloid differentiation. Boster Bio makes this antibody available for research use. It is not intended for diagnostic procedures or resale. It can be used to distinguish MYADM from other types of samples.

MYADM is an eukaryotic member of the MAL family, which has seven transmembrane domains that are hydrophobic. It shares 75% of the sequences in the transmembrane regions with mouse. It is linked to myeloid differentiation and can be found widely in bone marrow cells and other tissues. It may be an effective marker for hematopoietic differentiation as it has orthologs in the human, porcine and monkey genomes.

Trans-regulatory elements within the human genome are able to identify its antigens. The cis-element-based targeted genes discovery method is expected to be broadly useful. It is also expected to be an effective treatment for cancer as well as other diseases that are a result of myeloid differentiation. Monoclonal antibody can be used to diagnose, treat and prevent a wide variety of diseases through targeting the MYADM genes.

Primer Pairs

Many species have been able find the MYB gene. Its protein product regulates different flowering processes. Its gene product is also responsible for the production of anthocyanin pigments. These characteristics are tightly linked to human health, well-being, and wellbeing. The MYB gene was discovered in soybean and petunia GmMYB cDNAs. The genome is composed of two subtypes.

MYB genes encode proteins which trigger flavonoid biosynthesis. They share R2 and R3 regions as well as two amino acid motif. The GmMYB gene has only one intron, while other MYB genes contain two. These results demonstrate that these primer pairs are capable of mapping the MYB gene to multiple locations. These results are summarized in Table S1.

Clinical Applications

The MYB gene encodes a protein that has therapeutic potential and is essential in myeloid and B-cell malignancies. Although the protein cannot be produced by healthy cells, it can be identified in human blood using the qRT-PCR. This discovery has numerous clinical applications. It is especially useful for patients suffering from blood cancers, like leukemia. Here are some examples of cancers connected to MYB.

This gene is present in various types of cancers, including lung, breast and melanomas. The expression of the MYB gene is closely linked with the development of these cancers. It is also used as a marker for diagnosis. However, more investigation is needed to discover the way in which B-Myb is expressed in tumors. It is available in serum, blood and urine.

The transcription factor cmyb is implicated in the process of cardiac differentiation and the proliferation of smooth muscle cells in vascular systems but not in the formation of contractile SMCs. In embryos with chimeric chromosomes the MYB-/ cell lineage is not present. However in the heart, c-mybcells have decreased gene expression. This results in a decrease in SM differentiation. These findings are in agreement with the absence of SM-like contractions found in wild-type EBs.

One way to recognize tumors is to detect the presence of MYB by using compositions that contain MYPOP, an MYB-related gene. The MYB gene has numerous clinical applications, such as tumor detection and a wide range of treatment options. There is a broad range of uses for MYB, so these are just a few examples. If you'd like to know more, continue reading to learn more about MYB and its clinical applications.

The B-Myb gene regulates the expression of genes in colorectal carcinoma. Although its role is unclear and its expression is not fully understood, the overexpression of MYB enhances tumorigenesis. In orthotopic nude mouse models, B-Myb overexpression increased the rate of cell proliferation and the growth of tumors. The removal of B-Myb reduced the harmful effects. A novel transcriptional target, E2F2, is also involved in the MYB gene.

Safety

The MYB protein family includes a highly conserved DNA-binding domain and numerous C termini that function as trans-acting spheres and perform various MYB-related functions. The protein is composed of 52 repeats of amino acid residues that are hydrophobic. The tryptophan-rich core forms a solid structure. The protein has three a-helices which form an HTH (helix-turn-helix) structure, while the third helix is involved in DNA recognition.