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Mucin-16 Antibodies
AND MUC16 ELISA kits, Mucin-16 Proteins
Many biological assays use antibodies to detect Mucin-16, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Mucin-16 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Mucin-16 antibodies...
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MUC16 Infographic by Boster Bio
All MUC16 Products
Product
Figures
Specificity
Applications
Price
Human CA125/MUC16 ELISA Kit PicoKine®
1 Citations 6 Q&As
Human
ELISA
$499
Cat # EK1471
96 wells/kit, with removable strips.
Cat # EK1471
96 wells/kit, with removable strips.
Anti-MUC16/Ca125 Rabbit Monoclonal Antibody
1 Citations
Human
Flow Cytometry, IF, ICC, WB
$370
Cat # M01641
100 μl
Cat # M01641
100 μl
MUC16 Overview
Facts about Mucin-16.
Mucin-16 (MUC16)
Thought to provide a protective, lubricating barrier against allergens and infectious agents at mucosal surfaces. .
.
Gene Information
| Human | |
|---|---|
| Gene Name: | MUC16 |
| Uniprot: | Q8WXI7 |
| Entrez: | 94025 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
CA125 ovarian cancer antigen; CA125; CA-125; CA125MUC-16; FLJ14303; MUC16; mucin 16, cell surface associated; mucin-16; Ovarian cancer-related tumor marker CA125; Ovarian carcinoma antigen CA125
Molecular Weight
Mass (kDA):
1519.175 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19p13.2 |
| Sequence: | 19; NC_000019.10 (8848840..9010390, complement) |
Tissue Specificity
Expressed in corneal and conjunctival epithelia (at protein level). Overexpressed in ovarian carcinomas and ovarian low malignant potential (LMP) tumors as compared to the expression in normal ovarian tissue and ovarian adenomas.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Secreted, extracellular space. May be liberated into the extracellular space following the phosphorylation of the intracellular C-terminus which induces the proteolytic cleavage and liberation of the extracellular domain.
Diseases
- Malignant Neoplasms
- Ovarian Neoplasm
- Neoplasms
- Malignant Neoplasm Of Ovary
- Epithelial Ovarian Cancer
- Carcinoma
- Malignant Paraganglionic Neoplasm
- Adenocarcinoma
- Neoplasm Metastasis
- Neoplasms, Glandular And Epithelial
- Conjunctival Diseases
- Tissue Adhesions
- Cystadenocarcinoma, Serous
Pathways
- Cell Adhesion
- Pathogenesis
- Secretion
- Glycosylation
- Cell Growth
- Transport
- Immune Response
- Reverse Transcription
- Localization
- Proteolysis
- Mucus Secretion
- Cell Cycle
- Cell Differentiation
PTMs
- Glycosylation
- Cleavage
- Phosphorylation
Research Areas
- Cellular Markers
- Extracellular Matrix
- Tumor Biomarkers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MUC16
bosterbio.com/bosterbio-gene-info-cards/MUC16
References
PMID: 12218296 by O'Brien T.J., et al. The CA 125 gene: a newly discovered extension of the glycosylated N- terminal domain doubles the size of this extracellular superstructure.
PMID: 11786729 by O'Brien T.J., et al. The CA 125 gene: an extracellular superstructure dominated by repeat sequences.
2 Publications of Boster Mucin-16 Antibodies & ELISA Kits
- PubMed ID: 32765681, Wang H,Yan C,Ye H. Overexpression of MUC16 predicts favourable prognosis in MUC1...
- PubMed ID: 29221185, Li W, Zhang X, Wang J, Li M, Cao C, Tan J, Ma D, Gao Q. Oncotarget. 2017 Oct 6;8...
*More publications can be found for each product on its corresponding product page