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- Table of Contents
Facts about Poly(A) RNA polymerase, mitochondrial.
Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs until their degradation is initiated.
Human | |
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Gene Name: | MTPAP |
Uniprot: | Q9NVV4 |
Entrez: | 55149 |
Belongs to: |
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DNA polymerase type-B-like family |
EC 2.7.7.19; FLJ10486; mitochondrial poly(A) polymerase; mtPAP; PAP associated domain containing 1; PAP; PAP-associated domain-containing protein 1; PAPD1SPAX4; poly(A) RNA polymerase, mitochondrial; Polynucleotide adenylyltransferase; Terminal uridylyltransferase 1; TUTase 1
Mass (kDA):
66.172 kDA
Human | |
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Location: | 10p11.23 |
Sequence: | 10; NC_000010.11 (30309801..30349338, complement) |
Ubiquitous, with stronger expression in tissues with high energy requirements: heart, brain, and skeletal muscle.
Cytoplasm. Mitochondrion.
PMID: 15547249 by Tomecki R., et al. Identification of a novel human nuclear-encoded mitochondrial poly(A) polymerase.
PMID: 15769737 by Nagaike T., et al. Human mitochondrial mRNAs are stabilized with polyadenylation regulated by mitochondria-specific poly(A) polymerase and polynucleotide phosphorylase.