This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
MTOR Antibodies
AND MTOR ELISA kits, MTOR Proteins
Many biological assays use antibodies to detect MTOR, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MTOR in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MTOR antibodies...
Previous: CCN2
Next: CENPI
MTOR Infographic by Boster Bio
All MTOR Products
Product
Figures
Specificity
Applications
Price
Anti-Phospho-mTOR (S2481) Rabbit Monoclonal Antibody
5 Citations 4 Q&As
Human, Mouse, Rat
WB
$370
Cat # P00003-1
100 μl
Cat # P00003-1
100 μl
Anti-Phospho-mTOR (S2448) Rabbit Monoclonal Antibody
3 Citations 6 Q&As
Human, Mouse, Rat
IHC, WB
$370
Cat # P00003
100 μl
Cat # P00003
100 μl
Anti-mTOR/Tor Rabbit Monoclonal Antibody
4 Citations 17 Q&As
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M00003
100 μl
Cat # M00003
100 μl
Anti-mTOR Rabbit Monoclonal Antibody, Clone#RM274
3 Citations 16 Q&As
Human
IHC, WB
$431
Cat # M00003-1
100uL
Cat # M00003-1
100uL
Anti-mTOR/MTOR Antibody Picoband®
6 Citations 16 Q&As
Human, Monkey
ELISA, IHC, WB
$370
Cat # A00003-2
100 μg/vial
Cat # A00003-2
100 μg/vial
Human, Mouse, Rat
ELISA
$480
Cat # EKC1389
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1389
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2319
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2319
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2466
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2466
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA, IF, IHC, ICC, WB
$380
Cat # A00003S2481
100ul
Cat # A00003S2481
100ul
MTOR Overview
Facts about Serine/threonine-protein kinase mTOR.
Serine/threonine-protein kinase mTOR (MTOR)
Serine/threonine protein kinase that is a fundamental regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly modulates the phosphorylation of at least 800 proteins.
Functions as part of 2 structurally and functionally different signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E).
Gene Information
| Human | |
|---|---|
| Gene Name: | MTOR |
| Uniprot: | P42345 |
| Entrez: | 2475 |
Family
| Belongs to: |
|---|
| PI3/PI4-kinase family |
Alternative Names
EC 2.7.11.1; FK506 binding protein 12-rapamycin associated protein 1; FK506 binding protein 12-rapamycin associated protein 2; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP12-rapamycin complex-associated protein; FLJ44809; FRAP; FRAP1; FRAP1FKBP12-rapamycin complex-associated protein 1; FRAP2; Mammalian target of rapamycin; mechanistic target of rapamycin (serine/threonine kinase); Mechanistic target of rapamycin; MTOR; RAFT1; rapamycin and FKBP12 target 1; rapamycin associated protein FRAP2; Rapamycin target protein 1; RAPT1FKBP-rapamycin associated protein; serine/thr
Molecular Weight
Mass (kDA):
288.892 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p36.22 |
| Sequence: | 1; NC_000001.11 (11106535..11273497, complement) |
Tissue Specificity
Expressed in numerous tissues, with highest levels in testis.
Subcellular Localizations
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome. Cytoplasm. Nucleus, PML body. Microsome membrane. Lysosome membrane. Shuttles between cytoplasm and nucleus. Accumulates in the nucleus in response to hypoxia (By similarity). Targeting to lysosomes depends on amino acid availability and RRAGA and RRAGB (PubMed:18497260, PubMed:20381137). Lysosome targeting also depends on interaction with MEAK7. Translocates
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Cell Transformation, Neoplastic
- Tuberous Sclerosis
- Sclerosis
- Tumor Angiogenesis
- Malignant Neoplasm Of Breast
- Renal Cell Carcinoma
- Neoplasm Metastasis
- Malignant Paraganglionic Neoplasm
- Kidney Neoplasm
Interacting Proteins
- AKT1
- DEPTOR
- EIF4EBP1
- FKBP1A
- GTF3C2
- MLST8
- MTMR3
- PREX1
- RAB1A
- RHEB
Pathways
- Cell Growth
- Translation
- Cell Proliferation
- Cell Cycle
- Autophagy
- Cell Death
- Angiogenesis
- Pathogenesis
- Cell Cycle Arrest
- Aging
- Localization
- Secretion
- Transport
PTMs
- Phosphorylation
- Dephosphorylation
- Cleavage
- Ubiquitination
- Oxidation
- Methylation
- Acetylation
- Myristoylation
- Farnesylation
- Reduction
Research Areas
- Cancer
- Macroautophagy
- mTOR Pathway
- Phospho-Specific
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MTOR
bosterbio.com/bosterbio-gene-info-cards/MTOR
References
PMID: 8008069 by Brown E.J., et al. A mammalian protein targeted by G1-arresting rapamycin-receptor complex.
PMID: 9653645 by Onyango P., et al. Molecular cloning and expression analysis of five novel genes in chromosome 1p36.
10 Publications of Boster MTOR Antibodies & ELISA Kits
- PubMed ID: 10.3892/mmr.2021.11938, Hydrogen sulfide ameliorates doxorubicin‑induced myocardial fibrosis in rats v...
- PubMed ID: 10.3892/mmr.2017.6437, Expression of TGF-β1/mTOR signaling pathway in pathological scar fibroblasts
- PubMed ID: 10.1016/j.envpol.2021.116556, Mechanisms underlying reproductive toxicity induced by nickel nanoparticles iden...
- PubMed ID: 30787269, Xia Y,Zhang G,Han C,Ma K,Guo X,Wan F,Kou L,Yin S,Liu L,Huang J,Xiong N,Wang T.Mi...
- PubMed ID: 33649809, Nie L,Liu M,Chen J,Wu Q,Li Y,Yi J,Zheng X,Zhang J,Chu C,Yang J.Hydrogen sulfide ...
- PubMed ID: 33537831, Zhang X,Zhang L,Chen Z,Li S,Che B, Wang N,Chen J,Xu C,Wei C.Exogenous spermine a...
- PubMed ID: -, Lu Kong,Yongya Wu,Wangcheng Hu,Lin Liu,Yuying Xue,Geyu Liang,Mechanisms underlyi...
- PubMed ID: 32755651, Shao CS,Zhou XH,Zheng XX,Huang Q.Ganoderic acid D induces synergistic autophagic...
- PubMed ID: 25063028, Correlation between autophagy of osteoblasts and oxidative stress of osteoporosi...
- PubMed ID: 29904395, Rapamycin provides anti%u2011epileptogenic effect in a rat model of post%u2011tr...
*More publications can be found for each product on its corresponding product page