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- Table of Contents
Facts about Myotubularin-related protein 6.
1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3 phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells.
Human | |
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Gene Name: | MTMR6 |
Uniprot: | Q9Y217 |
Entrez: | 9107 |
Belongs to: |
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protein-tyrosine phosphatase family |
EC 3.1.3; EC 3.1.3.-; EC 3.1.3.48; myotubularin related protein 6; myotubularin-related protein 6
Mass (kDA):
71.968 kDA
Human | |
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Location: | 13q12.13 |
Sequence: | 13; NC_000013.11 (25246201..25287512, complement) |
Expressed in CD4+ T-cells.
Cytoplasm. Endoplasmic reticulum-Golgi intermediate compartment. Endoplasmic reticulum. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, perinuclear region. Localizes to ruffles during EGF-induced macropinocytosis (By similarity). Colocalizes with MTMR9 to the perinuclear region (PubMed:19038970). Partially localizes to the endoplasmic reticulum (PubMed:19038970). Co-localizes with RAB1B to the endoplasmic reticulum-Golgi intermediate compartment and to the peri-Golgi region (By similarity).
PMID: 12890864 by Mochizuki Y., et al. Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9.
PMID: 9736772 by Laporte J., et al. Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human.