MTHFD1L Antibodies

AND MTHFD1L ELISA kits, MTHFD1L Proteins

Many biological assays use antibodies to detect MTHFD1L, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MTHFD1L in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MTHFD1L antibodies...

We validate the specificity of these antibodies to MTHFD1L by testing them on tissues known to express MTHFD1L positively and negatively. Browse below to find the MTHFD1L antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MTHFD1L Infographic by Boster Bio

All MTHFD1L Products

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Price

Anti-MTHFD1L Antibody

Human, Mouse, Rat

IHC, WB

$405
Cat # A06289
100ul

Anti-MTHFD1L Antibody Picoband®

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, ICC, WB

$370
Cat # A06289-1
100 μg/vial

MTHFD1L Overview

Facts about Monofunctional C1-tetrahydrofolate synthase, mitochondrial.

MTHFD1L 3D structure. Source: alphafold

Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L)

May supply the missing metabolic reaction required to connect the mitochondria and the cytoplasm in the mammalian version of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic actions of MTHFD2. .

Gene Information

Human
Gene Name:	MTHFD1L
Uniprot:	Q6UB35
Entrez:	25902

Family

Belongs to:

No superfamily

Alternative Names

10-formyl-THF synthetase; dJ292B18.2; DKFZp586G1517; EC 6.3.4.3; FLJ21145; formyltetrahydrofolate synthetase domain containing 1; Formyltetrahydrofolate synthetase; FTHFSDC1; methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like; mitochondrial C1-tetrahydrofolate synthase; mitochondrial C1-tetrahydrofolate synthetase; monofunctional C1-tetrahydrofolate synthase, mitochondrial; MTC1THFS

Molecular Weight

Mass (kDA):
105.79 kDA

Genomic Context


Human

Location:	6q25.1
Sequence:	6; NC_000006.12 (150865679..151101887)

Tissue Specificity

Detected in most tissues, highest expression found in placenta, thymus and brain. Low expression is found in liver and skeletal muscle. Up-regulated in colon adenocarcinoma.

Subcellular Localizations

Mitochondrion.

Diseases

Coronary Artery Disease
Alzheimer's Disease
Coronary Heart Disease
Infarction
Myocardial Infarction
Dysequilibrium Syndrome
Heart Diseases
Malignant Neoplasms
Diabetes Mellitus
Moyamoya Disease
Stenosis
Malignant Neoplasm Of Breast
Dementia

Cardiovascular Diseases
Neoplasms
Hyperlipidemia
5,10-methylenetetrahydrofolate Reductase Deficiency
Mammary Neoplasms
Cleft Lip
Cerebrovascular Disorders

Pathways

Methylation
Mrna Splicing
Cell Proliferation
Cell Cycle
Dna Methylation

PTMs

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MTHFD1L

References

PMID: 12937168 by Prasannan P., et al. Human mitochondrial C1-tetrahydrofolate synthase: gene structure, tissue distribution of the mRNA, and immunolocalization in Chinese hamster ovary calls.

PMID: 15013446 by Sugiura T., et al. A novel mitochondrial C1-tetrahydrofolate synthetase is upregulated in human colon adenocarcinoma.