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- Table of Contents
Facts about Mdm2-binding protein.
Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This boosts MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation.
Human | |
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Gene Name: | MTBP |
Uniprot: | Q96DY7 |
Entrez: | 27085 |
Belongs to: |
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MTBP family |
hMTBP; MDM2 (mouse double minute 2)-binding protein, 104kD; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) bindingprotein, 104kDa; mdm2-binding protein; MDM2BP
Mass (kDA):
102.193 kDA
Human | |
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Location: | 8q24.12 |
Sequence: | 8; NC_000008.11 (120445401..120523636) |
PMID: 15632057 by Brady M., et al. Regulation of p53 and MDM2 activity by MTBP.
*More publications can be found for each product on its corresponding product page