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- Table of Contents
1 Citations 1 Q&As
Facts about Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1.
Substrates include asialo- orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl- sphingomyelin was the best, followed by palmitoyl- sphingomyelin and lignoceroyl-sphingomyelin.
Human | |
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Gene Name: | B3GAT1 |
Uniprot: | Q9P2W7 |
Entrez: | 27087 |
Belongs to: |
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glycosyltransferase 43 family |
B3GAT1; beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P); Beta-1,3-glucuronyltransferase 1; CD57; EC 2.4.1.135; galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1; GLCATP; GlcAT-P; GLCATPGLCUATP; GLCUATP; glcUAT-P; Glucuronosyltransferase P; HNK1; LEU7; NK1; NK-1; UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase
Mass (kDA):
38.256 kDA
Human | |
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Location: | 11q25 |
Sequence: | 11; NC_000011.10 (134378504..134412242, complement) |
Mainly expressed in the brain.
[Isoform 1]: Golgi apparatus membrane; Single-pass type II membrane protein. Secreted.; [Isoform 2]: Golgi apparatus membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane. Secreted.
PMID: 10783264 by Mitsumoto Y., et al. Cloning and chromosomal mapping of human glucuronyltransferase involved in biosynthesis of the HNK-1 carbohydrate epitope.
PMID: 14993226 by Kakuda S., et al. Structural basis for acceptor substrate recognition of a human glucuronyltransferase, GlcAT-P, an enzyme critical in the biosynthesis of the carbohydrate epitope HNK-1.
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