MTAP Antibodies

AND MTAP ELISA kits, MTAP Proteins

Many biological assays use antibodies to detect MTAP, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MTAP in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MTAP antibodies...

We validate the specificity of these antibodies to MTAP by testing them on tissues known to express MTAP positively and negatively. Browse below to find the MTAP antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MTAP Infographic by Boster Bio

All MTAP Products

Product

Figures

Specificity

Applications

Price

Anti-MTAP Antibody

1 Q&As

Human

$341
Cat # A05448
100 µg

Anti-MTAP Antibody

Human, Mouse, Rat

IHC, WB

$405
Cat # A05448-1
100ul

Anti-MTAP Rabbit Monoclonal Antibody

Human, Mouse, Rat

Flow Cytometry, IP, IF, IHC, ICC, WB

$370
Cat # M05448
100 μl/vial

MTAP (NM_002451) Human Over-expression Lysate

Human

$628
Cat # LS004507
100 µg

Anti-MTAP Antibody Picoband™

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, ICC, WB

$370
Cat # A05448-2
100 µg/vial

MTAP Overview

Facts about S-methyl-5'-thioadenosine phosphorylase.

MTAP 3D structure. Source: alphafold

S-methyl-5'-thioadenosine phosphorylase (MTAP)

Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a significant by-product of polyamine biosynthesis.

Responsible for the initial step in the methionine salvage pathway after MTA was generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates.

Gene Information

Human
Gene Name:	MTAP
Uniprot:	Q13126
Entrez:	4507

Family

Belongs to:

PNP/MTAP phosphorylase family

Alternative Names

5'-methylthioadenosine phosphorylase; BDMF; C86fus; DMSFH; DMSMFH; EC 2.4.2.28; HEL-249; LGMBF; methylthioadenosine phosphorylase; MSAPMeSAdo phosphorylase; MTA phosphorylase; MTAP; MTAPase; S-methyl-5'-thioadenosine phosphorylase

Molecular Weight

Mass (kDA):
31.236 kDA

Genomic Context


Human

Location:	9p21.3
Sequence:	9; NC_000009.12 (21802636..21867081)

Tissue Specificity

Ubiquitously expressed.

Subcellular Localizations

Cytoplasm. Nucleus.

Diseases

Neoplasms
Malignant Neoplasms
Malignant Paraganglionic Neoplasm
Leukemia
Carcinoma
Melanoma
Acute Lymphocytic Leukemia
Malignant Neoplasm Of Lung
Skin Neoplasms
Cell Transformation, Neoplastic
Glioma
Lymphoma
Adult T-cell Lymphoma/leukemia

Neoplasm Metastasis
Brain Neoplasms
Adenocarcinoma
Malignant Squamous Cell Neoplasm
Bone Neoplasms
Lung Neoplasms
Non-small Cell Lung Carcinoma

Interacting Proteins

CENPH

Pathways

Methylation
Pathogenesis
Cell Growth
Quorum Sensing
Cell Cycle
Interphase
Dna Methylation
Localization
Cell Death
Pigmentation
Oncogenesis
Rna Interference
Aging

Adenine Salvage
Cell Proliferation
Demethylation
Cell Adhesion
Programmed Cell Death
Gene Silencing
Proteolysis

PTMs

Methylation
Cleavage
Demethylation
Phosphorylation

Reduction
Deamination
Deacetylation
Decarboxylation

Oxidation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MTAP

References

PMID: 7604019 by Olopade O.I., et al. Construction of a 2.8-megabase yeast artificial chromosome contig and cloning of the human methylthioadenosine phosphorylase gene from the tumor suppressor region on 9p21.

PMID: 8650244 by Nobori T., et al. Genomic cloning of methylthioadenosine phosphorylase: a purine metabolic enzyme deficient in multiple different cancers.