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MTA1 Antibodies
AND MTA1 ELISA kits, MTA1 Proteins
Many biological assays use antibodies to detect MTA1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MTA1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MTA1 antibodies...
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MTA1 Infographic by Boster Bio
All MTA1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA
$480
Cat # EKC1794
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1794
1 kit, containing one 96-well plate and all necessary reagents
MTA1 Overview
Facts about Metastasis-associated protein MTA1.
Metastasis-associated protein MTA1 (MTA1)
Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator. As a component of the histone-deacetylase multiprotein complex (NuRD), regulates transcription of its targets by changing the acetylation status of the target chromatin and cofactor accessibility to the target DNA.
Along with other elements of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A. Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3.
Gene Information
| Human | |
|---|---|
| Gene Name: | MTA1 |
| Uniprot: | Q13330 |
| Entrez: | 9112 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
metastasis associated 1; metastasis associated gene 1 protein; metastasis associated protein; metastasis-associated protein MTA1
Molecular Weight
Mass (kDA):
80.786 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 14q32.33 |
| Sequence: | 14; NC_000014.9 (105419827..105470729) |
Tissue Specificity
Widely expressed. High expression in brain, liver, kidney, and cardiac muscle, ovaries, adrenal glands and virgin mammary glands. Higher in tumors than in adjacent normal tissue from the same individual. Up-regulated in a wide variety of cancers including breast, liver, ovarian, and colorectal cancer and its expression levels are closely correlated with tumor aggressiveness and metastasis.
Subcellular Localizations
[Isoform Short]: Cytoplasm.; [Isoform Long]: Nucleus. Nucleus envelope. Cytoplasm. Cytoplasm, cytoskeleton. Associated with microtubules. Localization at the nuclear envelope is TPR-dependent.
Diseases
- Malignant Neoplasms
- Neoplasm Metastasis
- Neoplasms
- Carcinoma
- Cell Invasion
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Neoplasm Invasiveness
- Malignant Paraganglionic Neoplasm
- Metastatic Malignant Neoplasm To The Lymph Node
- Cell Transformation, Neoplastic
- Lymphatic Metastasis
Interacting Proteins
- CDKN2A
- EHMT2
- HDAC1
- HDAC2
- HIF1A
- IKZF1
- JUN
- KHDRBS2
- KPNA3
- KRT40
Pathways
- Chromatin Remodeling
- Histone Deacetylation
- Localization
- Cell Proliferation
- Angiogenesis
- Cell Migration
- Reverse Transcription
- Rna Interference
- Spermatogenesis
- Dna Repair
- Cell Cycle
- Methylation
- Cell Growth
PTMs
- Deacetylation
- Acetylation
- Phosphorylation
- Methylation
- Sumoylation
Research Areas
- Cancer
- Cellular Markers
- Chromatin Research
- Transcription Factors and Regulators
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MTA1
bosterbio.com/bosterbio-gene-info-cards/MTA1
References
PMID: 8083195 by Toh Y., et al. A novel candidate metastasis-associated gene, mta1, differentially expressed in highly metastatic mammary adenocarcinoma cell lines. cDNA cloning, expression, and protein analyses.
PMID: 7607577 by Toh Y., et al. Analysis of the complete sequence of the novel metastasis-associated candidate gene, mta1, differentially expressed in mammary adenocarcinoma and breast cancer cell lines.