Metallothionein-3 Antibodies

AND MT3 ELISA kits, Metallothionein-3 Proteins

Many biological assays use antibodies to detect Metallothionein-3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Metallothionein-3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Metallothionein-3 antibodies...

We validate the specificity of these antibodies to Metallothionein-3 by testing them on tissues known to express MT3 positively and negatively. Browse below to find the MT3 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MT3 Infographic by Boster Bio

All MT3 Products

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Specificity

Applications

Price

Human MT3 Recombinant Protein

SDS-PAGE

$265
Cat # PROTP25713
Starting from 20ug

MT3 (NM_005954) Human Over-expression Lysate

Human

$628
Cat # LS004504
100 µg

MT3 Overview

Facts about Metallothionein-3.

MT3 3D structure. Source: alphafold

Metallothionein-3 (MT3)

Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible quantity of cadmium.

Inhibits survival and neurite formation of cortical neurons in vitro. .

Gene Information

Human
Gene Name:	MT3
Uniprot:	P25713
Entrez:	4504

Family

Belongs to:

metallothionein superfamily

Alternative Names

GIFBmetallothionein-3; GIFGRIF; Growth inhibitory factor; metallothionein 3 (growth inhibitory factor (neurotrophic)); metallothionein 3; metallothionein-III; MT-3; MT-III

Molecular Weight

Mass (kDA):
6.927 kDA

Genomic Context


Human

Location:	16q13
Sequence:	16; NC_000016.10 (56589528..56591085)

Tissue Specificity

Abundant in a subset of astrocytes in the normal human brain, but greatly reduced in the Alzheimer disease (AD) brain.

Diseases

Malignant Neoplasms
Neoplasms
Lameness, Animal
Fracture
Horse Diseases
Carcinoma
Claudication (finding)
Malignant Neoplasm Of Breast
Diabetes Mellitus
Nervousness
Dysequilibrium Syndrome
Neoplasm Metastasis
Pain

Arthritis
Rheumatoid Arthritis
Tissue Adhesions
Alzheimer's Disease
Diabetes Mellitus, Insulin-dependent
Degenerative Polyarthritis
Brain Neoplasms

Interacting Proteins

TERF2IP
TTR

Pathways

Localization
Circadian Rhythm
Secretion
Transport
Aging
Methylation
Cell Proliferation
Pathogenesis
Cell Death
Cell Cycle
Cell Growth
Dna Methylation
S Phase

Habituation
Immune Response
Oxidative Phosphorylation
Translation
Angiogenesis
Cell Adhesion
Histone Modification

PTMs

Methylation
Phosphorylation
Demethylation
Oxidation

Reduction
Cleavage
Glycosylation
Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MT3

References

PMID: 1873033 by Uchida Y., et al. The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein.

PMID: 1631128 by Palmiter R.D., et al. MT-III, a brain-specific member of the metallothionein gene family.