MT-CO2 Antibodies

Cytochrome c oxidase subunit 2 (MT-CO2)

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex.

Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1. .

Gene Information

Human
Gene Name:	MT-CO2
Uniprot:	P00403
Entrez:

Family

Belongs to:
cytochrome c oxidase subunit 2 family

Alternative Names

COII; COX2; COXII; Cytochrome C Oxidase II; Cytochrome C Oxidase Polypeptide II; Cytochrome C Oxidase Subunit II; EC 1.9.3.1; Mitochondrially Encoded Cytochrome C Oxidase II; MTCO2

Molecular Weight

Mass (kDA):
25.565 kDA

Genomic Context

Human
Location:
Sequence:	;

Subcellular Localizations

Mitochondrion inner membrane; Multi-pass membrane protein.

Diseases

• Malignant Neoplasms
• Inflammation
• Neoplasms
• Carcinoma
• Carcinogenesis
• Pain
• Tumor Angiogenesis
• Neoplasm Metastasis
• Cell Transformation, Neoplastic
• Colorectal Cancer
• Malignant Neoplasm Of Breast
• Colorectal Neoplasms
• Adenocarcinoma

• Mammary Neoplasms
• Inflammatory Response
• Malignant Squamous Cell Neoplasm
• Cell Invasion
• Arthritis
• Tissue Adhesions
• Malignant Tumor Of Colon

Pathways

• Angiogenesis
• Translation
• Cell Proliferation
• Pathogenesis
• Secretion
• Inflammatory Response
• Methylation
• Localization
• Mitochondrial Translation
• Transport
• Cell Growth
• Cell Death
• Aging

• Cell Cycle
• Immune Response
• Parturition
• Dna Methylation
• Regeneration
• Rna Processing
• Neuroprotection

PTMs

• Phosphorylation
• Methylation
• Cleavage
• Acetylation
• Oxidation
• Demethylation
• Nitration

• Reduction
• Dephosphorylation
• Nitrosylation
• Phosphorothioation
• Amidation
• Ubiquitination
• Biotinylation

• Glycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MT-CO2

The Best Uses Of The MT-CO2 Marker

You have found the right place if you are looking for a MTCO2 marker to use in a TFAMKD test. This article provides information about Boster Bio and the MT-CO2 Protein. I'll be discussing both the MT-CO2 proteins and the TFAMKD in the article.

Boster Bio

The MT-CO2 marker has several potential uses. One of these uses is to detect tumor cells' changes in mitochondrial protein and mRNA levels. Boster Bio's latest tool is especially useful in diagnosing cancer. This study used a mouse cell-line that expresses MTCO2 to determine the tumorigenicity and toxicity of a particular type of cancer cell line.

MT-CO2 Marker

The MTCO2 marker is a novel device that measures CO2 levels in the atmosphere. It can be used in many applications, including agricultural monitoring and environmental monitoring. This marker has a temperature controller that can be programmed and can be used with many types of gas cylinders. It is also very easy to use and doesn't require any training. The temperature of this marker will return over time to its ambient levels.

Using liquid CO2 as a marker has a number of advantages, especially for high-volume applications. The CO2 gas expands quickly and creates a thick cloud. Due to the rapid expansion of CO2, the cloud looks like snow. The marker can be overfilled if liquid CO2 is present.

While CO2-derived products are a key part of a net-zero CO2 economy, they are currently limited to small-scale uses in areas with favourable conditions and building codes. The IEA identified five types of CO2-derived products. These are just a few of the many industries that CO2 is used in. Others include fertilizer production, urea manufacture, metal fabrication, cooling and fire suppression. Although most of these uses of carbon dioxide are direct, there have been many new pathways to convert CO2 in fuels and chemicals. Although chemical conversion is gaining more commercial interest, it still faces many challenges.

TFAM KD

This study shows that TFAM KD correlates to lower MT-CO2 protein levels in HeLa cells and a lower mtDNA copy count. Furthermore, we show that TFAM KD increases MT-CO1 and MT-CO2 polypeptide levels in human osteosarcoma cells. Moreover, we demonstrate that MT-CO2 can be used to detect mtDNA copy number in a variety of cancer cells, including osteosarcoma cells.

TAZ downregulates transcriptional regulators in mitochondrial-biogenesis. Tfam levels decreased in mKO mouse models, but Nrf1, PGC1a, and Nrf2 expression did not change. TAZ KD myotubes also had comparable levels of Tfam as those in TAZ KO MEFs.

MT-CO2 protein

Complex IV contains the MTCO2 polypeptide encoded in mtDNA. This is a critical player in mitochondrial Biogenesis. It is found in both human cells and mouse cells. The MT-CO2 protein and its mRNA were increased four days after the induction of TFAM, whereas MT-ND6 protein expression was unchanged. Moreover MT-CO1 polypeptide levels were found to be higher in human osteosarcoma cells, and lower in mouse fibroblasts.

Recombination is used to synthesize MTCO2 in mitochondria. A mRNA molecule MT-CO2 was introduced into HeLa cells. It was then incubated for 24 hours with doxycycline. Various mitochondrial parameters were observed during the induction process. These included the production of TFAM, MT-CO2 and other proteins.