MSH3 Antibodies

AND MSH3 ELISA kits, MSH3 Proteins

Many biological assays use antibodies to detect MSH3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MSH3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MSH3 antibodies...

We validate the specificity of these antibodies to MSH3 by testing them on tissues known to express MSH3 positively and negatively. Browse below to find the MSH3 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MSH3 Infographic by Boster Bio

All MSH3 Products

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Product

Figures

Specificity

Applications

Price

Anti-MSH3 (A80) Antibody

Human, Mouse, Rat

IHC, WB

$405
Cat # A02455
100ul

MSH3 (NM_002439) Human Over-expression Lysate

Human

$960
Cat # LS004437
100 µg

MSH3 Overview

Facts about DNA mismatch repair protein Msh3.

MSH3 3D structure. Source: alphafold

DNA mismatch repair protein Msh3 (MSH3)

Part of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta that binds to DNA mismatches thereby initiating DNA repair.

When bound, the MutS beta heterodimer bends the DNA helix and protects approximately 20 base pairs. MutS beta acknowledges large insertion- deletion loops (IDL) up to 13 nucleotides long.

Gene Information

Human
Gene Name:	MSH3
Uniprot:	P20585
Entrez:	4437

Family

Belongs to:

DNA mismatch repair MutS family

Alternative Names

Divergent upstream protein; DNA mismatch repair protein Msh3; DUC1; DUG; DUPMGC163306; hMSH3; Mismatch repair protein 1; MRP1MGC163308; mutS (E. coli) homolog 3; mutS homolog 3 (E. coli)

Molecular Weight

Mass (kDA):
127.412 kDA

Genomic Context


Human

Location:	5q14.1
Sequence:	5; NC_000005.10 (80654652..80876815)

Diseases

Malignant Neoplasms
Neoplasms
Microsatellite Instability
Colorectal Cancer
Carcinoma
Colorectal Neoplasms
Hereditary Nonpolyposis Colorectal Cancer
Mutation, Out-of-frame
Malignant Tumor Of Colon
Carcinogenesis
Cell Transformation, Neoplastic
Trinucleotide Repeat Expansion

Leukemia
Adenocarcinoma
Genomic Instability
Malignant Neoplasm Of Stomach
Colonic Neoplasms
Turcot Syndrome (disorder)
Stomach Neoplasms

Interacting Proteins

MLH1
MSH2
PCNA

Pathways

Mismatch Repair
Dna Repair
Transport
Dna Replication
Methylation
Drug Resistance
Localization
Pathogenesis
Meiosis
Cell Cycle
Gene Conversion
Double-strand Break Repair
Cell Death

Mitotic Recombination
Cell Growth
Aging
Drug Transport
Cell Differentiation
Dna Methylation
Prophase

PTMs

Methylation
Deamination
Demethylation
Cleavage

Phosphorylation
Phosphorothioation
Reduction
Glycosylation

Research Areas

DNA Repair
Mismatch Repair
Neuroscience

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MSH3

References

PMID: 2722860 by Fujii H., et al. Isolation and characterization of cDNA clones derived from the divergently transcribed gene in the region upstream from the human dihydrofolate reductase gene.

PMID: 8942985 by Acharya S., et al. hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6.