MutS protein homolog 5 Antibodies

AND MSH5 ELISA kits, MutS protein homolog 5 Proteins

Many biological assays use antibodies to detect MutS protein homolog 5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MutS protein homolog 5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MutS protein homolog 5 antibodies...

We validate the specificity of these antibodies to MutS protein homolog 5 by testing them on tissues known to express MSH5 positively and negatively. Browse below to find the MSH5 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MSH5 Infographic by Boster Bio

All MSH5 Products

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MSH5 (NM_002441) Human Recombinant Protein

$1249
Cat # PROTO43196
20 µg

MSH5 (NM_002441) Human Over-expression Lysate

Human

$628
Cat # LS004439
100 µg

MSH5 Overview

Facts about MutS protein homolog 5.

MSH5 3D structure. Source: alphafold

MutS protein homolog 5 (MSH5)

Involved in DNA mismatch repair and meiotic recombination processes. Facilitates crossovers between homologs during meiosis (By similarity).

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Gene Information

Human
Gene Name:	MSH5
Uniprot:	O43196
Entrez:	4439

Family

Belongs to:

DNA mismatch repair MutS family

Alternative Names

DKFZp434C1615; G7; hMSH5; MGC2939; mutS (E. coli) homolog 5; mutS homolog 5 (E. coli); mutS protein homolog 5; MUTSH5; NG23

Molecular Weight

Mass (kDA):
92.875 kDA

Genomic Context


Human

Location:	6p21.33
Sequence:	6; NC_000006.12 (31739948..31762678)

Tissue Specificity

Widely expressed, with high levels in testis and ovary, including granulosa cells (PubMed:9740671, PubMed:28175301). Also expressed in fetal ovary and adrenal gland (PubMed:28175301).

Diseases

Malignant Neoplasms
Common Variable Immunodeficiency
Immunologic Deficiency Syndromes
Neoplasms
Infertility
Male Infertility
Azoospermia
Infective Disorder
Hereditary Nonpolyposis Colorectal Cancer
Dysequilibrium Syndrome
Malignant Neoplasm Of Lung
Colorectal Cancer
Cell Invasion

Autoimmunity
Adenocarcinoma
Sterility
Carcinoma
Immunoglobulin A Deficiency (disorder)
Primary Immune Deficiency Disorder
Hypogammaglobulinemia

Interacting Proteins

ABL1
MSH4

Pathways

Meiosis
Mismatch Repair
Prophase
Localization
Dna Repair
Pachytene
Pathogenesis
Spermatogenesis
Meiosis I
Male Meiosis
Metaphase
Gene Conversion
Female Meiosis

Recombinational Repair
Zygotene
Nuclear Export
Synaptonemal Complex Assembly
Oocyte Development
Fertilization
Dna Recombination

PTMs

Phosphorylation

Methylation

Research Areas

DNA Repair
Mismatch Repair
modENCODE Antibodies

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MSH5

References

PMID: 9740671 by Her C., et al. Cloning, structural characterization, and chromosomal localization of the human orthologue of Saccharomyces cerevisiae MSH5 gene.

PMID: 10029069 by Bocker T., et al. hMSH5: a human MutS homologue that forms a novel heterodimer with hMSH4 and is expressed during spermatogenesis.