MRAP Antibodies

AND MRAP ELISA kits, MRAP Proteins

Many biological assays use antibodies to detect MRAP, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MRAP in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MRAP antibodies...

We validate the specificity of these antibodies to MRAP by testing them on tissues known to express MRAP positively and negatively. Browse below to find the MRAP antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MRAP Infographic by Boster Bio

All MRAP Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-MRAP Antibody

Human

ELISA, WB

$380
Cat # A04500
100ul

MRAP (NM_206898) Human Recombinant Protein

$813
Cat # PROTQ8TCY5
20 µg

MRAP (NM_206898) Human Over-expression Lysate

Human

$628
Cat # LS056246
100 µg

MRAP Overview

Facts about Melanocortin-2 receptor accessory protein.

MRAP 3D structure. Source: alphafold

Melanocortin-2 receptor accessory protein (MRAP)

Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R).
Acts by boosting ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP from the receptors.

Desired both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells.

Gene Information

Human
Gene Name:	MRAP
Uniprot:	Q8TCY5
Entrez:	56246

Family

Belongs to:

MRAP family

Alternative Names

B27GCCD2; C21orf61chromosome 21 open reading frame 61; FALPFGD2; Fat cell-specific low molecular weight protein; Fat tissue-specific low MW protein; melanocortin 2 receptor accessory protein; melanocortin-2 receptor accessory protein

Molecular Weight

Mass (kDA):
19.136 kDA

Genomic Context


Human

Location:	21q22.11
Sequence:	21; NC_000021.9 (32291813..32314784)

Tissue Specificity

Expressed in adrenal cortex, testis, breast, thyroid, lymph node, ovary and fat. Expressed in adipose tissues.

Subcellular Localizations

Cell membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein. The formation of antiparallel homo- and heterodimers suggest that N- and C-terminus can both localize in the cytoplasmic and extracellular parts, depending on the context (PubMed:20371771). Upon insulin stimulation, it is redistributed into spotty structures throughout the cytoplasm.

Diseases

Adrenal Gland Hypofunction
Cerebrovascular Accident
Adrenal Gland Diseases
Hypoglycemia
Liver Neoplasms
Glucocorticoid Deficiency With Achalasia
Heart Failure
Neoplasms
Pituitary Diseases
Esophageal Achalasia
Liver Carcinoma
Malignant Paraganglionic Neoplasm

Hyperpigmentation
Genetic Diseases, Inborn
Carcinoma
Pain
Hypoplasia
Congenital Absence Of Adrenal Gland

Interacting Proteins

MC1R
MC2R
MC3R
MC4R
MC5R

MRAP2

Pathways

Localization
Reflex
Secretion
Transport
Cell Cycle
Gland Development
Glycosylation
Mineralocorticoid Secretion
Pathogenesis
Adrenal Gland Development
Developmental Process
Pigmentation
Protein Secretion

Sensitization
Translation
Cell Differentiation
Vasoconstriction
Bioluminescence
Vasodilation
Endocytosis

PTMs

Phosphorylation

Glycosylation

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MRAP

References

PMID: 12054497 by Xu A., et al. Identification of novel putative membrane proteins selectively expressed during adipose conversion of 3T3-L1 cells.

PMID: 12036298 by Gardiner K., et al. Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis.