MR1 Antibodies

AND MR1 ELISA kits, MR1 Proteins

Many biological assays use antibodies to detect MR1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MR1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MR1 antibodies...

We validate the specificity of these antibodies to MR1 by testing them on tissues known to express MR1 positively and negatively. Browse below to find the MR1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MR1 Infographic by Boster Bio

All MR1 Products

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Specificity

Applications

Price

Anti-MR1 Antibody Picoband®

3 Q&As

Human, Mouse, Rat

ELISA, Flow Cytometry, WB

$370
Cat # A00618-1
100 μg/vial

MR1 (NM_001531) Human Over-expression Lysate

Human

$628
Cat # LS003140
100 µg

MR1 Overview

Facts about Major histocompatibility complex class I-related gene protein.

MR1 3D structure. Source: alphafold

Major histocompatibility complex class I-related gene protein (MR1)

Antigen-presenting molecule specialized in presenting microbial vitamin B metabolites. Involved in the development and growth of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T- cells (MAIT).

MAIT lymphocytes are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent.

Gene Information

Human
Gene Name:	MR1
Uniprot:	Q95460
Entrez:	3140

Family

Belongs to:

MHC class I family

Alternative Names

Class I histocompatibility antigen-like protein; FLJ31593; H2ls; HLALS; major histocompatibility complex class I-related gene protein; major histocompatibility complex, class I-like sequence; major histocompatibility complex, class I-related; MHC class I-like antigen MR-1; MHC class I-related gene protein; MHC class-I related-gene protein; MR1

Molecular Weight

Mass (kDA):
39.366 kDA

Genomic Context


Human

Location:	1q25.3
Sequence:	1; NC_000001.11 (181033392..181061938)

Tissue Specificity

Ubiquitous.

Subcellular Localizations

Cell membrane; Single-pass membrane protein; Extracellular side. Endoplasmic reticulum.; [Isoform 4]: Secreted.; [Isoform 3]: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane. The larger proportion remains in the ER in an immature state. The subset that reach cell surface does it through a B2M-independent pathway.

Diseases

Neoplasms
Autoimmune Reaction
Malignant Neoplasms
Autoimmunity
Decreased Immunologic Activity [pe]
Fibrosis
Inflammation
Sclerosis
Infective Disorder
Bacterial Infections
Autoimmune Diseases
Depressive Disorder
Diabetes Mellitus, Experimental

Graft-vs-host Disease
Multiple Sclerosis
Diabetes Mellitus
Experimental Autoimmune Encephalomyelitis
Pain
Diabetes Mellitus, Insulin-dependent
Crohn Disease

Interacting Proteins

B2M
FATE1

Pathways

Immune Response
Cell Activation
Cytokine Production
Tolerance Induction
Cell Proliferation
Pathogenesis
Cell Development
Localization
Cell Death
Secretion
T Cell Activation
Sensitization
Transport

Reflex
Glycosylation
Hypersensitivity
Cell Cycle
Innate Immune Response
Bioluminescence
Mammary Gland Development

PTMs

Phosphorylation
Glycosylation
Nitration

Phosphorothioation
Hydroxylation
Iodination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MR1

References

PMID: 7624800 by Hashimoto K., et al. A gene outside the human MHC related to classical HLA class I genes.

PMID: 11019920 by Parra-Cuadrado J.F., et al. A study on the polymorphism of human MHC class I-related MR1 gene and identification of an MR1-like pseudogene.