MPP2 Antibodies

MAGUK p55 subfamily member 2 (MPP2)

Postsynaptic MAGUK scaffold protein that links CADM1 cell adhesion molecules into core elements of the postsynaptic density (By similarity). In CA1 pyramidal neurons, required for synaptic KCNN2-containing channel function and long-term potentiation expression (By similarity).

Appears to negatively regulate SRC function in epithelial cells (PubMed:19665017). .

Gene Information

Human
Gene Name:	MPP2
Uniprot:	Q14168
Entrez:	4355

Family

Belongs to:
MAGUK family

Alternative Names

Discs large homolog 2; DKFZp686A06252; DKFZp686J2189; DKFZp761D0712; DLG2discs large, homolog 2; MAGUK p55 subfamily member 2; membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2); Protein MPP2

Molecular Weight

Mass (kDA):
64.581 kDA

Genomic Context

Human
Location:	17q21.31
Sequence:	17; NC_000017.11 (43875357..43909711, complement)

Subcellular Localizations

Cytoplasm, cytoskeleton. Membrane. Cell projection, dendrite. Cell junction, synapse, postsynaptic density. Prominently expressed in the postsynaptic densities of dendritic spines, is also detected in dendritic shafts.

Diseases

• Neoplasms
• Malignant Neoplasms
• Nervousness
• Tissue Adhesions
• Cell Invasion
• Lung Neoplasms
• Malignant Neoplasm Of Lung
• Chimera Disorder
• Adenocarcinoma
• Hypertrophy
• Respiratory Failure
• Adenocarcinoma Of Lung (disorder)
• Schizophrenia

• Retinoblastoma
• Adenoma
• Inflammation
• Cell Transformation, Neoplastic
• Cholangiocarcinoma
• Peripheral Nerve Injuries
• Muscular Dystrophy, Duchenne

Interacting Proteins

• LIN7A

Pathways

• Localization
• Cell Cycle
• Mitosis
• Synaptic Transmission
• Dna Replication
• Cell Adhesion
• Cell Proliferation
• Proteolysis
• Liver Development
• Regeneration
• Pathogenesis
• Rna Interference
• Transport

• Cell Migration
• Lung Development
• M Phase
• Vasculogenesis
• Regulation Of Dendritic Spine Morphogenesis
• Cytokinesis
• Cell Differentiation

PTMs

• Phosphorylation
• Palmitoylation

• Cleavage
• Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MPP2

Best Uses Of The MPP2 Marker From Boster Bio

High-affinity primary antibodies from Boster Bio are a great way to test MPP2 levels in your samples. There are many different flow procedures to choose from, so there are many things to consider when determining the best one for your experiment. These optimization guides and tips should help you make the best choice for your experiments. In addition, you can find a guide to MPP2 that will help you make the most of your Boster Bio system.

Boster Bio: High-affinity primary antibodies

As an antibody manufacturer, Boster offers a wide range of highly validated monoclonal antibodies. These antibodies are generated in-house and are derived from popular clones. Boster's high-affinity primary antibodies are tested in WB, IP, Western Blotting, and ELISA and come in liquid or granule forms. The MPP2 marker is a known antigen, but its exact location is not known.

MPP2 marker

The MPP2 marker is a specific protein that plays an important role in phosphorylation. Boster Bio provides high-affinity primary antibodies that are highly cited over the last 25 years and are trusted by the research community. Boster antibodies are validated on immunohistochemistry, ELISA, and Western Blotting. If you're trying to find the best use for this protein, consider the following tips and guides.

Optimization tips

Optimizing your flow cytometry experiments for the MPP2 marker begins with sample preparation. First, determine the antibody concentration. Next, determine the blocking buffer. Follow Boster Bio optimization tips for the MPP2 marker. This will help you ensure your sample is free of dead cells and debris. Finally, optimize your cytometry procedure by using Boster Bio's flow cytometry guides. They contain detailed instructions and answer questions about sample preparation.