MPDZ Antibodies

AND MPDZ ELISA kits, MPDZ Proteins

Many biological assays use antibodies to detect MPDZ, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MPDZ in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MPDZ antibodies...

We validate the specificity of these antibodies to MPDZ by testing them on tissues known to express MPDZ positively and negatively. Browse below to find the MPDZ antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MPDZ Infographic by Boster Bio

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Anti-Multiple PDZ domain protein MPDZ Antibody

Human, Mouse, Rat

IHC, WB

$405
Cat # A03410
100ul

MPDZ Overview

Facts about Multiple PDZ domain protein.

MPDZ 3D structure. Source: alphafold

Multiple PDZ domain protein (MPDZ)

Interacts with HTR2C and provokes its clustering at the cell surface (By similarity). Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses.

Gene Information

Human
Gene Name:	MPDZ
Uniprot:	O75970
Entrez:	8777

Family

Belongs to:

No superfamily

Alternative Names

DKFZp781P216; FLJ25909; FLJ90240; Multi-PDZ domain protein 1; multiple PDZ domain protein; MUPP1FLJ34626

Molecular Weight

Mass (kDA):
221.618 kDA

Genomic Context


Human

Location:	9p23
Sequence:	9; NC_000009.12 (13105296..13279692, complement)

Tissue Specificity

Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas.

Subcellular Localizations

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Apical cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse, postsynaptic density. Cell projection, dendrite. Cell junction, tight junction. Cell junction, synapse. Cell junction, synapse, synaptosome. Associated with membranes. Colocalizes with HTR2C on the apical membrane of epithelial choroid plexus cells. Highly enriched in postsynaptic densities (PSD). Localized to punctae on dendrites of hippocampal neurons and colocalizes with the synaptic marker DLG4. Localized mainly in the Schmidt-Lanterman

Diseases

Neoplasms
Tissue Adhesions
Substance Withdrawal Syndrome
Nervousness
Withdrawal Seizure
Malignant Neoplasms
Leber Congenital Amaurosis
Retinal Degeneration
Retinitis Pigmentosa
Convulsions
Amaurosis

Retinal Dysplasia
Malignant Neoplasm Of Breast
Carcinoma
Dysplasia
Pituitary Diseases

Interacting Proteins

OR2AG1
PLEKHA1
Plekha2
SSTR3
TP53

Pathways

Localization
Cell Growth
Acrosome Reaction
Transport
Myelination
Exocytosis
Cell Proliferation
Secretion
Cell Adhesion
Cell Migration
Fertilization
Membrane Organization
Cell Cycle

Stem Cell Proliferation
Plasma Membrane Organization
Cell-cell Adhesion
Synaptic Transmission
Protein Transport
Dendritic Spine Morphogenesis
Cell Death

PTMs

Phosphorylation
Biotinylation
Cleavage

Acetylation
Dephosphorylation
Methylation

Research Areas

Adaptive Immunity
Immunology

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MPDZ

References

PMID: 9537516 by Ullmer C., et al. Cloning and characterization of MUPP1, a novel PDZ domain protein.

PMID: 11000240 by Lee S.S., et al. Multi-PDZ domain protein MUPP1 is a cellular target for both adenovirus E4-ORF1 and high-risk papillomavirus type 18 E6 oncoproteins.