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- Table of Contents
Facts about Transcriptional activator MN1.
Promotes maturation and normal use of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL. Necessary for normal development of the membranous bones of the skull (By similarity).
Human | |
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Gene Name: | MN1 |
Uniprot: | Q10571 |
Entrez: | 4330 |
Belongs to: |
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No superfamily |
Transcriptional activator MN1
Mass (kDA):
136.001 kDA
Human | |
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Location: | 22q12.1 |
Sequence: | 22; NC_000022.11 (27748277..27801756, complement) |
Ubiquitously expressed. Highest levels in skeletal muscle.
PMID: 7731706 by Deprez R.H.L., et al. Cloning and characterization of MN1, a gene from chromosome 22q11, which is disrupted by a balanced translocation in a meningioma.
PMID: 7731705 by Buijs A., et al. Translocation (12;22) (p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11.