MMS19 nucleotide excision repair protein homolog (MMS19)

Key part of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complicated, MMS19 serves as an adapter between early-acting CIA components along with a subset of cellular target iron-sulfur proteins like ERCC2/XPD, FANCJ and RTEL1, thereby playing a crucial role in nucleotide excision repair (NER), homologous recombination- mediated double-strand break DNA repair, DNA replication and RNA polymerase II (POL II) transcription (PubMed:22678362, PubMed:22678361, PubMed:29225034, PubMed:23585563).

As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD (PubMed:20797633). Indirectly functions as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some part of the TFIIH-machinery (PubMed:11279242).