MMP15 Antibodies

Matrix metalloproteinase-15 (MMP15)

Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A.

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Gene Information

Human
Gene Name:	MMP15
Uniprot:	P51511
Entrez:	4324

Family

Belongs to:
peptidase M10A family

Alternative Names

EC 3.4.24; EC 3.4.24.-; EC 3.4.24.80; matrix metallopeptidase 15 (membrane-inserted); matrix metalloproteinase 15 (membrane-inserted); Membrane-type matrix metalloproteinase 2; Membrane-type-2 matrix metalloproteinase; MMP15; MMP-15; MT2-MMP; MT2-MMPMT2MMP; MTMMP2MT-MMP 2; SMCP-2matrix metalloproteinase-15

Molecular Weight

Mass (kDA):
75.807 kDA

Genomic Context

Human
Location:	16q21
Sequence:	16; NC_000016.10 (58025754..58046901)

Tissue Specificity

Appeared to be synthesized preferentially in liver, placenta, testis, colon and intestine. Substantial amounts are also detected in pancreas, kidney, lung, heart and skeletal muscle.

Subcellular Localizations

Membrane; Single-pass type I membrane protein; Extracellular side.

Diseases

• Neoplasms
• Cell Invasion
• Neoplasm Metastasis
• Carcinoma
• Malignant Neoplasms
• Neoplasm Invasiveness
• Malignant Paraganglionic Neoplasm
• Mammary Neoplasms
• Cell Transformation, Neoplastic
• Adenocarcinoma
• Tumor Progression
• Glioma

• Malignant Squamous Cell Neoplasm
• Metastatic Malignant Neoplasm To The Lymph Node
• Tumor Angiogenesis
• Tissue Adhesions
• Malignant Neoplasm Of Breast
• Inflammation
• Carcinogenesis

Interacting Proteins

• PROC

Pathways

• Localization
• Angiogenesis
• Cell Adhesion
• Proteolysis
• Pathogenesis
• Rna Interference
• Transport
• Cell Proliferation
• Cell Migration
• Gland Development
• Tube Formation
• Dna Methylation
• Metaphase

• Mammary Gland Development
• Vasculogenesis
• Syncytium Formation
• Mesenchymal Cell Migration
• Methylation
• Menstruation
• Reverse Transcription

PTMs

• Cleavage

• Methylation

Research Areas

• Extracellular Matrix

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MMP15

Boster Bio - Best Uses Of The MMP15 Marker

Are you interested about Steven Boster, His antibodies for MMP15 Marker, and more? This article will give you an overview of Boster's history, antibodies, and products. Boster produces primary antibodies for this marker that have received good citations over the last 25 years and have been tested and validated in Western Blotting, Immunohistochemistry, and ELISA as well as other techniques.

His antibodies

MMP-15 staining, one of the most prominent cancer markers, is one. It is a protein that shows strong staining in the cytoplasm of tumor cells. MMP-2 (most prominent staining) is found in the cytoplasm of cancer cells. MMP-15 (most predominant staining) is found in the cells' cytoplasm. This marker has many uses in cancer research.

MMP-15 antibodies, which are used to detect the protein, have been shown in association with breast cancer progression. The expression of MMPs has been associated with higher levels of tumour cells. It has also been shown to be associated with increased invasion of tumour cells and the building of metastatic formations. These studies have highlighted the importance of His antibodies in cancer research. Although the MMP15 markers have many uses, there are only few that are particularly useful.

MMPs play a critical role in the invasion or growth of tumor cells. MMPs are key players in the formation of metastatic forms, so antibodies to these proteins prove useful in cancer research. Multiple researches have shown that MMP15 antibodies are capable of detecting tumors that have migrated from distant locations. Zhao et.al. The expression of MMP26 was also elevated in prostate cancer patients, as demonstrated by Zhao et al.

These studies show that His antibodies are useful in MMP research. His antibodies are able to identify both active and latent enzyme forms. They also provide the best method to evaluate MMPs related to tumors. These antibodies can also be used to evaluate the effects of obesity on mothers and children. However, they require expert guidance. Before using His antibodies for cancer research, it is important that you consult a physician.