MMADHC Antibodies

AND MMADHC ELISA kits, MMADHC Proteins

Many biological assays use antibodies to detect MMADHC, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MMADHC in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MMADHC antibodies...

We validate the specificity of these antibodies to MMADHC by testing them on tissues known to express MMADHC positively and negatively. Browse below to find the MMADHC antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MMADHC Infographic by Boster Bio

All MMADHC Products

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Product

Figures

Specificity

Applications

Price

Human MMADHC Recombinant Protein

SDS-PAGE

$250
Cat # PROTQ9H3L0
Starting from 20ug

Anti-C2ORF25 (MMADHC) Mouse Monoclonal Antibody [Clone ID: OTI1G4]

Human, Mouse, Rat

$523
Cat # M09934
100 µl

C2ORF25 (MMADHC) (NM_015702) Human Over-expression Lysate

Human

$628
Cat # LS027249
100 µg

MMADHC Overview

Facts about Methylmalonic aciduria and homocystinuria type D protein, mitochondrial.

MMADHC 3D structure. Source: alphafold

Methylmalonic aciduria and homocystinuria type D protein, mitochondrial (MMADHC)

Involved in cobalamin metabolism (PubMed:18385497, PubMed:23415655, PubMed:24722857, PubMed:26364851). Plays a role in regulating the biosynthesis of two coenzymes, methylcobalamin and adenosylcobalamin (PubMed:18385497, PubMed:24722857).

Plays a role in regulating the ratio of methylcobalamin and adenosylcobalamin (PubMed:23415655, PubMed:24722857). Promotes oxidation of cob(II)alamin jumped to MMACHC (PubMed:26364851).

Gene Information

Human
Gene Name:	MMADHC
Uniprot:	Q9H3L0
Entrez:	27249

Family

Belongs to:

No superfamily

Alternative Names

cblD; chromosome 2 open reading frame 25; methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria; mitochondrial; protein C2orf25, mitochondrial

Molecular Weight

Mass (kDA):
32.94 kDA

Genomic Context


Human

Location:	2q23.2
Sequence:	2; NC_000002.12 (149569637..149587775, complement)

Tissue Specificity

Widely expressed at high levels.

Subcellular Localizations

Cytoplasm. Mitochondrion.

Diseases

Homocystinuria
Methylmalonic Acidemia
Inborn Errors Of Metabolism
Vitamin B 12 Deficiency
Acidemia
Cardiomyopathy, Dilated
Methylmalonic Acidemia With Homocystinuria
Fetal Growth Retardation
Growth Retardation

Cardiomyopathies
Nervousness
Homocystinaemia

Pathways

Translation

PTMs

Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MMADHC

References

PMID: 18385497 by Coelho D., et al. Gene identification for the cblD defect of vitamin B12 metabolism.

PMID: 21071249 by Plesa M., et al. Interaction between MMACHC and MMADHC, two human proteins participating in intracellular vitamin B(1)(2) metabolism.