Melanophilin Antibodies

AND MLPH ELISA kits, Melanophilin Proteins

Many biological assays use antibodies to detect Melanophilin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Melanophilin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Melanophilin antibodies...

We validate the specificity of these antibodies to Melanophilin by testing them on tissues known to express MLPH positively and negatively. Browse below to find the MLPH antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: Septin9 Next: SLC25A23

MLPH Infographic by Boster Bio

All MLPH Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-Melanophilin MLPH Antibody

Human, Mouse, Rat

IF, IHC, ICC, WB

$405
Cat # A06081
100 ul

Anti-Melanophilin (MLPH) Mouse Monoclonal Antibody [Clone ID: OTI6E3]

Human

IHC, WB

$523
Cat # M06081
100 µl

Melanophilin (MLPH) (NM_024101) Human Over-expression Lysate

Human

$628
Cat # LS079083
100 µg

Anti-MLPH Antibody Picoband®

Human

ELISA, IF, ICC, WB

$370
Cat # A06081-3
100 µg/vial

MLPH Overview

Facts about Melanophilin.

MLPH 3D structure. Source: alphafold

Melanophilin (MLPH)

Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A.

Gene Information

Human
Gene Name:	MLPH
Uniprot:	Q9BV36
Entrez:	79083

Family

Belongs to:

No superfamily

Alternative Names

exophilin-3; l(1)-3Rk; l1Rk3; ln; melanophilin; MGC2771; MGC59733; SLAC2A; Slac-2a; SLAC2-A; Slp homolog lacking C2 domains a; Synaptotagmin-like protein 2a

Molecular Weight

Mass (kDA):
65.949 kDA

Genomic Context


Human

Location:	2q37.3
Sequence:	2; NC_000002.12 (237486410..237555322)

Subcellular Localizations

Cytoplasm.

Diseases

Hypopigmentation-immunodeficiency Disease
Immunologic Deficiency Syndromes
Melanoma
Piebaldism
Albinism
Hypopigmentation Disorder
Pigmentation Disorders
Malignant Neoplasms
Metabolic Bone Disorder
Griscelli Syndrome, Type 2
Dysplasia
Neoplasms
Inflammation

Nervousness
Chediak-higashi Syndrome
Dermatitis
Cell Transformation, Neoplastic
Nervous System Disorder
Lymphohistiocytosis, Hemophagocytic
Immune System Diseases

Interacting Proteins

RAB27A
RAB27B

Pathways

Transport
Melanosome Transport
Pigmentation
Localization
Exocytosis
Vesicle Transport
Secretion
Intracellular Transport
Proteolysis
Cell Differentiation
Pathogenesis
Cell Adhesion
Secretory Pathway

Melanocyte Differentiation
Insulin Secretion
Cell Division
Pigment Granule Transport
Regulation Of Intracellular Transport
Rna Interference
Lymphocyte Proliferation

PTMs

Phosphorylation

Reduction

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MLPH

References

PMID: 12062444 by Nagashima K., et al. Melanophilin directly links Rab27a and myosin Va through its distinct coiled-coil regions.

PMID: 12897212 by Menasche G., et al. Griscelli syndrome restricted to hypopigmentation results from a melanophilin defect (GS3) or a MYO5A F-exon deletion (GS1).